@article{oai:repo.qst.go.jp:00055236,
 author = {手島, 昭樹 and 松浦, 成昭 and 池田, 聡子 and 水野, 裕一 and 尾方, 俊至 and 野島, 久美恵 and 古澤, 佳也 and 手島 昭樹 and 松浦 成昭 and 池田 聡子 and 水野 裕一 and 尾方 俊至 and 野島 久美恵 and 古澤 佳也},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {The purpose of this study is to investigate the effect of heavy ion on the processes of metastasis, especially angiogenesis. Heavy ion radiation therapy has attracted attention as an effective modality for cancer therapy because of its highly lethal effects, but the effects of heavy ion irradiation on angiogenesis have not been reported. Angiogenesis is not only a prerequisite for tumor growth and expression but also a major factor affecting the metastatic spread of malignant cells. In vivo, angiogenesis was inhibited by carbon ion irradiation in the dorsal air sac (DAS) model. In vitro, capillary-like tube structures in 3-D culture were destroyed after carbon ion irradiation concomitant with the inhibition of cell motility, migration, invasiveness, and proliferation. These data suggest that heavy ion could inhibit angiogenesis, thus leading to inhibition of tumor growth and metastasis.},
 pages = {53--54},
 title = {重粒子線によるがんの転移課程に及ぼす影響},
 volume = {2002},
 year = {2003}
}