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癌関連遺伝子からみた重粒子線治療の基礎的研究
https://repo.qst.go.jp/records/55235
https://repo.qst.go.jp/records/55235b9a014f0-616c-40a1-86ff-4fe048ae5e27
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-01-23 | |||||
| タイトル | ||||||
| タイトル | 癌関連遺伝子からみた重粒子線治療の基礎的研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
大西, 武雄
× 大西, 武雄× 高橋, 昭久× 浅川, 勇雄× 大西, 健× 玉本, 哲朗× 古澤, 佳也× 大西 武雄× 高橋 昭久× 浅川 勇雄× 大西 健× 玉本 哲郎× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate the dependency of p53 gene status on the thermal enhancement of cellular sensitivity against different levels of linear energy transfer (LET) of X-rays or carbon-ion (C-) beams. We used p53 null H1299 cells transfected with wild-type p53(wtp53) or mutated p53(mp53) gene. We found that (i) there was no significant difference in sensitivity to high LET radiations above 30 KeV/um among H1299, H1299/mp53 and H1299/wtp53 cells, although the radiosensitivity of H1299/wtp53 cells against X-rays was higher (1.2-fold) than those of H1299 and H1299/mp53 cells; (ii) there was an synergistic enhancement with heat to radiosensitivity against below 70 KeV/um in H1299/ wtp53 cells alone; (iii) low-LET radiations effectively induced apoptosis in H1299/wtp53 cells as compared with H1299 and H1299/mp53 cells; (iv) high-LET radiations as compared with low-LET radiation at iso-survival dose effectively induced apoptosis in H1299/wtp53 cells; (v) high-LET radiations induced p53-independent apoptosis in H1299 and H1299/mp53 cells; (vi) thermal enhancement of cellular sensitivity against X-ray might be due to induction of p53-dependent apoptosis. Our findings suggest that thermal enhancement of radiosensitivity may be resulted in p53-dependent apoptosis instead ofinhibition of p53-dependent cell survival system(s)through either regulation of the cell cycle orinduction of DNA repair. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2002, p. 51-52, 発行日 2003-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
