@article{oai:repo.qst.go.jp:00055235,
 author = {大西, 武雄 and 高橋, 昭久 and 浅川, 勇雄 and 大西, 健 and 玉本, 哲朗 and 古澤, 佳也 and 大西 武雄 and 高橋 昭久 and 浅川 勇雄 and 大西 健 and 玉本 哲郎 and 古澤 佳也},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {To investigate the dependency of p53 gene status on the thermal enhancement of cellular sensitivity against different levels of linear energy transfer
(LET) of X-rays or carbon-ion (C-) beams. We used p53 null H1299 cells transfected with wild-type p53(wtp53) or mutated p53(mp53) gene. We found
that (i) there was no significant difference in sensitivity to high LET radiations above 30 KeV/um among H1299, H1299/mp53 and H1299/wtp53 cells, although the radiosensitivity of H1299/wtp53 cells against X-rays was higher (1.2-fold) than those of H1299 and H1299/mp53 cells; (ii) there was an synergistic enhancement with heat to radiosensitivity against below 70 KeV/um in H1299/ wtp53 cells alone; (iii) low-LET radiations effectively induced apoptosis in H1299/wtp53 cells as compared with H1299 and H1299/mp53 cells; (iv) high-LET radiations as compared with low-LET radiation at iso-survival dose effectively induced apoptosis in H1299/wtp53 cells; (v) high-LET radiations induced p53-independent apoptosis in H1299 and H1299/mp53 cells; (vi) thermal enhancement of cellular sensitivity against X-ray might be due to induction of p53-dependent apoptosis. Our findings suggest that thermal enhancement of radiosensitivity may be resulted in p53-dependent apoptosis instead ofinhibition of p53-dependent cell survival system(s)through either regulation of the cell cycle orinduction of DNA repair.},
 pages = {51--52},
 title = {癌関連遺伝子からみた重粒子線治療の基礎的研究},
 volume = {2002},
 year = {2003}
}