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Study of unrejoined chromosome breakage after low- and high-LET radiation in human fibroblast cells
https://repo.qst.go.jp/records/55189
https://repo.qst.go.jp/records/5518985005814-dc30-400e-bf22-abb93b46cdd8
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-06 | |||||
| タイトル | ||||||
| タイトル | Study of unrejoined chromosome breakage after low- and high-LET radiation in human fibroblast cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wu, Honglu
× Wu, Honglu× Furusawa, Yoshiya× George, Kerry× Kawata, Tetsuya× Willingham, Velonoca× A, Cucinotta Francesca× ウー ホングル× 古澤 佳也× ジョージ ケリー× 川田 哲也× クシノッタ フランク |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Reported studies of DNA breakage induced by radiation of various qualities have generally shown a higher fraction of unrejoined residue breaks after high-LET exposure. This observation is supported by the argument that DNA breaks produced by high-LET radiation are more complex and, thus, less likely to be repaired. We study here unrejoined breaks by examination of chromosome aberrations analyzed using fluorescence in situ hybridization (FISH) technique with whole chromosome specific probes together with human telomere probes. Previous, we have reported that the fraction of truly unrejoined breaks in chromosomes collected in metaphase was low, even after high-LET exposure. However, it is possible that cells with open break end are less likely than cells without chromosome breakage to reach mitosis. In this study we used a chemical-induced premature chromosome condensation (PCC) technique and found that the ratio of unrejoined to misrejoined chromosome breaks increased with LET values up to 440 keV/um. | |||||
| 書誌情報 |
Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC 巻 2002, p. 148-149, 発行日 2002-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
