@article{oai:repo.qst.go.jp:00055189,
 author = {Wu, Honglu and Furusawa, Yoshiya and George, Kerry and Kawata, Tetsuya and Willingham, Velonoca and A, Cucinotta Francesca and ウー ホングル and 古澤 佳也 and ジョージ ケリー and 川田 哲也 and クシノッタ フランク},
 journal = {Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC},
 month = {Apr},
 note = {Reported studies of DNA breakage induced by radiation of various qualities have generally shown a higher fraction of unrejoined residue breaks after high-LET exposure. This observation is supported by the argument that DNA breaks produced by high-LET radiation are more complex and, thus, less likely to be repaired. We study here unrejoined breaks by examination of chromosome aberrations analyzed using fluorescence in situ hybridization (FISH) technique with whole chromosome specific probes together with human telomere probes. Previous, we have reported that the fraction of truly unrejoined breaks in chromosomes collected in metaphase was low, even after high-LET exposure. However, it is possible that cells with open break end are less likely than cells without chromosome breakage to reach mitosis. In this study we used a chemical-induced premature chromosome condensation (PCC) technique and found that the ratio of unrejoined to misrejoined chromosome breaks increased with LET values up to 440 keV/um.},
 pages = {148--149},
 title = {Study of unrejoined chromosome breakage after low- and high-LET radiation in human fibroblast cells},
 volume = {2002},
 year = {2002}
}