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Role of transferring pathway of single molecules involved in irradiation induced bystander effec
https://repo.qst.go.jp/records/55188
https://repo.qst.go.jp/records/55188c3dc344d-6491-4eb5-abe0-a4c3dc8e8828
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-06 | |||||
| タイトル | ||||||
| タイトル | Role of transferring pathway of single molecules involved in irradiation induced bystander effec | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
邵, 春林
× 邵, 春林× 古澤, 佳也× 青木, 瑞穂× 安藤, 興一× Ｓｈａｏ Ｃｈｕｎｌｉｎ× 古澤 佳也× 青木 瑞穂× 安藤 興一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The factors and pathways of both medium and gap junction mediated-bystander effects were investigated. By co-cultivating unirradiated recipient human neoplastic salivary gland (HSG) cells with HSG donor cells irradiated by X-rays or 290 MeV/u carbon beams, it was found that cell proliferation and plating efficiency (PE) of the recipient HSG cells were increased, as well as micronucleus (MN) were concurrently induced. These medium-mediated effects were relative to the LET of irradiation, moreover, they were found to be generated from nitric oxide (NO) secreted from donor cells. On the other hand, when a confluent AG1522 normal fibroblast cell layer was irradiated by high-energy ion beams, it was found that a very low dose irradiation, of which only part of cell population was actually traversed by an particle, was much more effective in inducing cellular MN than a high dose irradiation. Both MN induction and G1-phase arrest induced by heavy ions irradiation was increased when the gap junction intercellular communication (GJIC) was enhanced by the treatment of 8-Br-cAMP, but they were reduced when the cells were treated by a GJIC inhibitor. In addition, the treatment of DMSO together with 8-Br-cAMP slight decreased the production of the G1-phase arrest. Our results showed that the irradiation-induced bystander effect could be produced by both medium-mediated factors and cell-to-cell communication. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2002, p. 95-96, 発行日 2002-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
