@article{oai:repo.qst.go.jp:00055188,
 author = {邵, 春林 and 古澤, 佳也 and 青木, 瑞穂 and 安藤, 興一 and Ｓｈａｏ Ｃｈｕｎｌｉｎ and 古澤 佳也 and 青木 瑞穂 and 安藤 興一},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {The factors and pathways of both medium and gap junction mediated-bystander effects were investigated. By co-cultivating unirradiated recipient human neoplastic salivary gland (HSG) cells with HSG donor cells irradiated by X-rays or 290 MeV/u carbon beams, it was found that cell proliferation and plating efficiency (PE) of the recipient HSG cells were increased, as well as micronucleus (MN) were concurrently induced. These medium-mediated effects were relative to the LET of irradiation, moreover, they were found to be generated from nitric oxide (NO) secreted from donor cells. On the other hand, when a confluent AG1522 normal fibroblast cell layer was irradiated by high-energy ion beams, it was found that a very low dose irradiation, of which only part of cell population was actually traversed by an particle, was much more effective in inducing cellular MN than a high dose irradiation. Both MN induction and G1-phase arrest induced by heavy ions irradiation was increased when the gap junction intercellular communication (GJIC) was enhanced by the treatment of 8-Br-cAMP, but they were reduced when the cells were treated by a GJIC inhibitor. In addition, the treatment of DMSO together with 8-Br-cAMP slight decreased the production of the G1-phase arrest. Our results showed that the irradiation-induced bystander effect could be produced by both medium-mediated factors and cell-to-cell communication.},
 pages = {95--96},
 title = {Role of transferring pathway of single molecules involved in irradiation induced bystander effec},
 volume = {2002},
 year = {2002}
}