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重粒子線照射後のDNA２本鎖切断修復因子の応答
https://repo.qst.go.jp/records/55131
https://repo.qst.go.jp/records/55131a3fcbdaf-b4fc-4afe-b5d9-449df27f00a1
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-09-04 | |||||
| タイトル | ||||||
| タイトル | 重粒子線照射後のDNA２本鎖切断修復因子の応答 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鈴木, 紀夫
× 鈴木, 紀夫× 冨田, 雅典× 松本, 義久× 古澤, 佳也× 安藤, 興一× 鈴木 紀夫× 冨田 雅典× 松本 義久× 古澤 佳也× 安藤 興一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | DNA-PK, ATM and NBS1 have been considered critical molecules in initial step of DNA double-strand break (DSB) repair process. In this study, we examined the radio-sensitivity for carbon ions of defective cell lines in DNA-PKcs (DNA-PK catalytic subunit), ATM or NBS1 and of cells treated with wortmannin, an inhibitor of PI3-kinase, DNA-PK and ATM. We found that DNA-PKcs-, ATM- or NBS1-defective cell lines were more sensitive to both X-rays and carbon ions than wild-type cell lines. The RBEs determined by D10 of carbon ions relative to X-rays were about 2.0 in the defective cell lines. On the other hand, RBEs of wortmannin treated or untreated wild-type cells (LM217 or HeLa cells) were 1.59 or 1.29 (with 10 or 20 uM wortmannin) and 1.95 or 2.17 (untreated) respectively. RBE of carbon ions differed between DSB repair-defective cells and wortmannin treated wild-type cells. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2002, p. 93-94, 発行日 2002-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
