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重粒子線の細胞周期への影響における細胞種間比較
https://repo.qst.go.jp/records/55102
https://repo.qst.go.jp/records/55102e7ecaeee-4adb-4c26-9267-1f7c04b56f62
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-09-01 | |||||
| タイトル | ||||||
| タイトル | 重粒子線の細胞周期への影響における細胞種間比較 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
笠井, 清美
× 笠井, 清美× 笠井 清美 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We studied the cell cycle progression in cultured rodent and human cells after irradiation with heavy ion beams. Asynchronous Chinese hamster V79 cells and human normal fibroblasts NB1RGB were irradiated with carbon ion beam (LET = 30 - 250 keV/um) and Si ion beam (245 keV/um) in monolayer. FCM data showed that more than 80% of the V79 cells were accumulated in G2/M phase from 4 to 12 h with a peak around 5 to 6 h after irradiation of carbon ion beams. The maximum value and the width of the peak increased with irradiation dose. Relative biological effectiveness (RBE) of G2 arrest, calculated from the half value width of the peaks, increased with LET up to 170 keV/um. RBE values for LET higher than 77 keV/um were bigger than those for the cell inactivation. V79 cells showed no G1 arrest. In contrast, NB1RGB showed long G1 arrest and smaller peak of G2 population compared with V79 cells. They have gone to G1 phase after long stay at G1 to G2 phase after irradiation after irradiation by even low LET C beams. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2001, p. 123-124, 発行日 2001-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
