WEKO3
アイテム
急性膵島細胞死でみた重粒子線のＲＢＥ
https://repo.qst.go.jp/records/55066
https://repo.qst.go.jp/records/550662aecc039-0d89-4258-a9ff-acb2da20dfe6
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-08-26 | |||||
| タイトル | ||||||
| タイトル | 急性膵島細胞死でみた重粒子線のＲＢＥ | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
坪内, 進
× 坪内, 進× 福津, 久美子× 五日市, ひろみ× 村上, 正弘× 古澤, 佳也× 笠井, 清美× 金井, 達明× 小池, 幸子× 安藤, 興一× 河野, 明広× 松下, 悟× 大原, 弘× 谷田貝, 文夫× 加納, 永一× 坪内 進× 福津 久美子× 五日市 ひろみ× 村上 正弘× 古澤 佳也× 笠井 清美× 金井 達明× 小池 幸子× 安藤 興一× 河野 明広× 松下 悟× 大原 弘× 谷田貝 文夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | At this fiscal year, first of all this project was designed to obtain RBE of 290MeV carbon and 400MeV neon beams for acute cell death of pancreatic islets of golden hamster (Mesocricetus auratus) in the condition of in vitro system. This new trials, however, resulted in ill success possibly in terms of physiological conditions of this In vitro system. As the limited chance of experiments, this new trial was tentatively shelved for the time being. In return for this problems in vivo experiments for low LET region (32.5KeV/u) of neon beams was performed. This results together with those previously obtained for 200KeV x-ray, 70MeV proton, 290MeV carbon (60KeV/u) and neon (100KeV/u) beams were reconsidered. Dose response relations (25, 50, 100, 150, and 200Gy respectively) in acute cell death of pancreatic islets studied histologically after whole body irradiation of 3 weeks young male golden hamster with lower LET neon beams (32.5KeV/u). Results indicated that Do of neon beams (32.5KeV/u) was 49Gy. Previously obtained Do data for 200KeV x-ray, 70MeV proton, 290MeV carbon (60KeV/u) and neon (100KeV/u) beams were 38Gy, 35-40Gy, 75Gy, and150-250Gy respectively. From these data estimated RBE of neon (100KeV/u and 32.5KeV/u), carbon (60KeV/u), and proton beams were 0.19-0.25, 0.78, 0.51, 0.95-1.1, respectively. Therefore the order of radiosensitivities of islets cells with these various heavy ion beams was dependent on the order of each LET value irrespective of beam species. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2000, p. 77-78, 発行日 2001-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
