@article{oai:repo.qst.go.jp:00055066, author = {坪内, 進 and 福津, 久美子 and 五日市, ひろみ and 村上, 正弘 and 古澤, 佳也 and 笠井, 清美 and 金井, 達明 and 小池, 幸子 and 安藤, 興一 and 河野, 明広 and 松下, 悟 and 大原, 弘 and 谷田貝, 文夫 and 加納, 永一 and 坪内 進 and 福津 久美子 and 五日市 ひろみ and 村上 正弘 and 古澤 佳也 and 笠井 清美 and 金井 達明 and 小池 幸子 and 安藤 興一 and 河野 明広 and 松下 悟 and 大原 弘 and 谷田貝 文夫}, journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書}, month = {Apr}, note = {At this fiscal year, first of all this project was designed to obtain RBE of 290MeV carbon and 400MeV neon beams for acute cell death of pancreatic islets of golden hamster (Mesocricetus auratus) in the condition of in vitro system. This new trials, however, resulted in ill success possibly in terms of physiological conditions of this In vitro system. As the limited chance of experiments, this new trial was tentatively shelved for the time being. In return for this problems in vivo experiments for low LET region (32.5KeV/u) of neon beams was performed. This results together with those previously obtained for 200KeV x-ray, 70MeV proton, 290MeV carbon (60KeV/u) and neon (100KeV/u) beams were reconsidered. Dose response relations (25, 50, 100, 150, and 200Gy respectively) in acute cell death of pancreatic islets studied histologically after whole body irradiation of 3 weeks young male golden hamster with lower LET neon beams (32.5KeV/u). Results indicated that Do of neon beams (32.5KeV/u) was 49Gy. Previously obtained Do data for 200KeV x-ray, 70MeV proton, 290MeV carbon (60KeV/u) and neon (100KeV/u) beams were 38Gy, 35-40Gy, 75Gy, and150-250Gy respectively. From these data estimated RBE of neon (100KeV/u and 32.5KeV/u), carbon (60KeV/u), and proton beams were 0.19-0.25, 0.78, 0.51, 0.95-1.1, respectively. Therefore the order of radiosensitivities of islets cells with these various heavy ion beams was dependent on the order of each LET value irrespective of beam species.}, pages = {77--78}, title = {急性膵島細胞死でみた重粒子線のRBE}, volume = {2000}, year = {2001} }