WEKO3
アイテム
Effects of Radioprotectors (e.g. RibCys & Ascorbate) on Mutation in Cultured Mammalian Cells by Carbon Beam
https://repo.qst.go.jp/records/55003
https://repo.qst.go.jp/records/55003b7fa8b4e-5b42-41be-8ac5-4f6d4e91efa0
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-06-14 | |||||
| タイトル | ||||||
| タイトル | Effects of Radioprotectors (e.g. RibCys & Ascorbate) on Mutation in Cultured Mammalian Cells by Carbon Beam | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Waldren, Charles
× Waldren, Charles× Ueno, A× Vannais, Diane× Zhang, Y Y× Tatsumi, Kouichi× Furusawa, Yoshiya× Roberts, Jc× 巽 紘一× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Several radical scavenging chemicals including dimethylsulfoxide (DMSO), n-acetylcysteine (NAC), ascorbate (AsA) and RibCys [2,S-D-ribo-(1',2',3',4'-tetrahydroxybutly)-thizolidine-(R)-ca-riboxylic acid] were evaluated for their ability to alter the genotoxicity (lethality and mutagenicity) of high LET carbon beam (290 MeV/:, LET = 100 KeV/μ m). Of these, AsA (5 mM) appeared to be the most promising in that it reduced mutant yields without affecting survival. NAC and RibCys also showed promise. The maximum reduction in mutant yield with the protocols used for AsA was about 50%. Asa effectively reduced mutation even when added after irradiation. Our working hypothesis is based on work of Koyama et al. 1 who found that IR, in their case X-rays could induce stable organic radicals, which were inactivated by AsA, which were especially important for mutagenicity, and , by implication, the carcinogenicity of ionizing radiation. | |||||
| 書誌情報 |
Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC p. 101-103, 発行日 2001-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
