WEKO3
アイテム
重粒子線の線種および線質とＲＢＥおよびＯＥＲのスペクトル（重粒子線の線種および線質と障害からの回復）
https://repo.qst.go.jp/records/54992
https://repo.qst.go.jp/records/549926f821e7b-99d1-4aed-b815-9f82d5c19257
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-06-11 | |||||
| タイトル | ||||||
| タイトル | 重粒子線の線種および線質とＲＢＥおよびＯＥＲのスペクトル（重粒子線の線種および線質と障害からの回復） | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
古澤, 佳也
× 古澤, 佳也× 青木, 瑞穂× 内海, 博司× 大塚, 健太郎× 月原, 一浩× 檜枝, 光太郎× 船田, 文× 佐藤, 一史× 高倉, かほる× 古澤 佳也× 青木 瑞穂× 内海 博司× 檜枝 光太郎× 高倉 かほる |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To determine radiobiological mechanisms and repair efficiencies of DNA double-strand breaks as (dsb) a function of LET and/or ion-species, HSG (human salivary gland tumor) and DT40 (chicken leukemia B) cells were exposed to heavy-ion beams obtained from HIMAC. The LET dependences of cell killing on the knockout mutant cells of DNA-dsb repair genes (ku70-/-, rad54-/-, ku70-/-rad54-/-, and the parent DT40), and that of PLDR and SLDR in HSG cells were investigated. LET dependencies of repair from DNA-dsb in DT40 cells showed a big difference revealed by the difference in presence or absence of sister chromatid and repair genes in the cell. A usual LET-RBE relationship was observed in repair sufficient cells, but no peak of RBE was found in repair deficient cells. This suggests that the peak of the RBE caused by misrepair of DNA dsb. LET dependency of SLDR on HSG cells determined by X-ray following exposure of different high-LET as primary irradiation was difficult to find. This may caused that the SLD in the cell produced by the penumbra of the ion-beam. |
|||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 p. 104-105, 発行日 2001-04 |
|||||
| 出版者 | ||||||
| 出版者 | 放医研 | |||||
