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In vivo visualization of electro-assisted delivery of nanoparticles using optical imaging
https://repo.qst.go.jp/records/54516
https://repo.qst.go.jp/records/545163fc16a38-268a-4dd9-aaf1-e30103a5ccb8
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-21 | |||||
| タイトル | ||||||
| タイトル | In vivo visualization of electro-assisted delivery of nanoparticles using optical imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Atanasova, Severina
× Atanasova, Severina× Lazarova, Desislava× Pancheva, Nikolova-Lefterova Biliana× Zhelev, Zhivko× I.Tsoneva× Aoki, Ichio× Bakalova-Zheleva, Rumiana× アタナソヴァ セヴァリナ× ラザロヴァ デシスラヴァ× ニコロヴァレフタロヴ＆＃６５５３３； ．咼螢▲福＆＃６５５３３；× Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ× 青木 伊知男× バカロバ ルミアナ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study was designed to investigate whether electroporation can facilitate the delivery of drugs inside tumors, using quantum dot (QD)-loaded polymersomes as a model. The main goal was to increase the local concentration of anticancer drugs avoiding side-effects. The experiments were performed on colon-cancer grafted mice (Balb/c) using Maestro EX Imaging System. Electroporation facilitated the delivery of nanoparticles inside the tumor. A significant difference in the fluorescence intensity between electroporated and non-electroporated mice was observed in cancer area even 24 hours after treatment with nanoparticles. The data suggest that electro-assisted delivery of size-controlled long-circulating polymersomes in cancer is a promising therapeutic strategy, especially for treatment of solid tumors. | |||||
| 書誌情報 |
ANTICANCER RESEARCH 巻 34, p. 5819-5821, 発行日 2014-10 |
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