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Quantitative characteristics of clustered DNA damage in irradiated cells by heavy ion beams
https://repo.qst.go.jp/records/54504
https://repo.qst.go.jp/records/54504ec39a645-a000-48fc-9a36-d4beb1c7b574
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-17 | |||||
| タイトル | ||||||
| タイトル | Quantitative characteristics of clustered DNA damage in irradiated cells by heavy ion beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Terato, Hiroaki
× Terato, Hiroaki× Shimazaki-Tokuyama, Yuka× Inoue, Yuko× Furusawa, Yoshiya× 寺東 宏明× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Heavy ion beam as typical high linear energy transfer (LET) radiation produces more expanding ionization domain around their tracks than low LET radiation such as X-rays and gamma rays. Thus, heavy ion beam can cause more densely accumulated damage cluster in the target DNA, termed clustered DNA damage. This damage exhibits difficulty for repair and inhibition of DNA replication with its complex structure [ 1]. So, clustered DNA damage is thought to be strongly involved in the biological effectiveness of heavy ion beam. However, a lot of studies have presented no certain correlation between yields of clustered DNA damage and severity of radiation effect. We previously indicated that the yields of clustered DNA damage decreased with increasing LET in the DNA molecules irradiated in test tubes with gamma rays, and carbon and iron ion beams whose showed different LET, respectively [ 2]. In this study, we aimed to reveal correlation between clustered DNA damage and the LET of heavy ion beam in the irradiated cells. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 55, 号 s1, p. i89-i90, 発行日 2014-04 |
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| 出版者 | ||||||
| 出版者 | Oxford Univ. Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrt173 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jrr.oxfordjournals.org/content/55/suppl_1/i89.full | |||||
| 関連名称 | http://jrr.oxfordjournals.org/content/55/suppl_1/i89.full | |||||
