@inproceedings{oai:repo.qst.go.jp:00054504, author = {Terato, Hiroaki and Shimazaki-Tokuyama, Yuka and Inoue, Yuko and Furusawa, Yoshiya and 寺東 宏明 and 古澤 佳也}, book = {Journal of Radiation Research}, issue = {s1}, month = {Apr}, note = {Heavy ion beam as typical high linear energy transfer (LET) radiation produces more expanding ionization domain around their tracks than low LET radiation such as X-rays and gamma rays. Thus, heavy ion beam can cause more densely accumulated damage cluster in the target DNA, termed clustered DNA damage. This damage exhibits difficulty for repair and inhibition of DNA replication with its complex structure [ 1]. So, clustered DNA damage is thought to be strongly involved in the biological effectiveness of heavy ion beam. However, a lot of studies have presented no certain correlation between yields of clustered DNA damage and severity of radiation effect. We previously indicated that the yields of clustered DNA damage decreased with increasing LET in the DNA molecules irradiated in test tubes with gamma rays, and carbon and iron ion beams whose showed different LET, respectively [ 2]. In this study, we aimed to reveal correlation between clustered DNA damage and the LET of heavy ion beam in the irradiated cells.}, pages = {i89--i90}, publisher = {Oxford Univ. Press}, title = {Quantitative characteristics of clustered DNA damage in irradiated cells by heavy ion beams}, volume = {55}, year = {2014} }