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Fractionated Irradiation of Carbon Beam and the Isoeffect Dose on Acute Reaction of Skin
https://repo.qst.go.jp/records/54497
https://repo.qst.go.jp/records/54497f944a9ae-fcdf-4ea5-a020-190243b65666
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-05-20 | |||||
| タイトル | ||||||
| タイトル | Fractionated Irradiation of Carbon Beam and the Isoeffect Dose on Acute Reaction of Skin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鵜澤, 玲子
× 鵜澤, 玲子× 平山, 亮一× 松本, 孔貴× 幸田, 華奈× 小池, 幸子× 安藤, 興一× 古澤, 佳也× 鵜澤 玲子× 平山 亮一× 松本 孔貴× 幸田 華奈× 小池 幸子× 安藤 興一× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose The aim of this study was to clear any specific LETs cause change in skin reaction. We irradiated mice feet with mono-energetic and SOBP carbon ions, to obtain dose response of early skin reaction at different LETs. Materials and methods Mice C3H/HeMsNrsf female mice aged 4 months old were used for this study. The animals were produced and maintained in specific pathogen-free (SPF) facilities. Irradiation The mice right hind legs received daily fractionated irradiation ranged from single to 6 fractions. Carbon ions (12C6+) were accelerated by the HIMAC synchrotron to 290 MeV/u. Irradiation was conducted using horizontal carbon-ion beams with a dose rate of ~3 Gy/min. We chose the LETs at entrance of plateau (20keV/μm) and the SOBP (proximal:40keV/μm, middle:45keV/μm, distal:60keV/μm, distal-end:80keV/μm). The reference beam was 137Cs γ-rays with a dose rate of 1.2 Gy/min. Skin reaction Skin reaction of the irradiated legs were scored every other day, between the14th and 35th post irradiation days. Our scoring scale consisted of 7 steps, ranging from 0.5 to 3.5.(1) The skin score analyzed a result by the method that described by Ando.(2) The Fe-plot proposed Douglas and Fowler was used as a multifraction linear quadratic model. A plot between the reciprocal of the isoeffect dose and the dose per fraction resulted in a straight line. Results Required isoeffect total dose increased linearly with the fraction numbers on a semi-logarithmic chart at LET 20- 60keV/µm SOBP beam. The isoeffect total dose decreased with increase of the LET. However, no increases of isoeffect total dose were observed at few fractionations at 80keV/µm. (data not shown) Using an Fe-plot, we analyzed the isoeffect total dose to evaluate the dependence on Carbon beam, or γ-ray. When I irradiate it by γ-ray, an Fe-plot shows linearly. But, irradiated by Carbon beam, an Fe-plot bent at low fractions. (Fig.1) Conclusion The LQ-model based Fe-plot could not fit skin reaction at few fractions at high-LET. |
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| 書誌情報 |
Journal of Radiation Research 巻 55, 号 S1, p. i135-i136, 発行日 2014-03 |
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| 出版者 | ||||||
| 出版者 | oxford university press | |||||
