{"created":"2023-05-15T14:39:40.921445+00:00","id":54497,"links":{},"metadata":{"_buckets":{"deposit":"4a01ed1e-d91b-48ab-a70c-1a16c02799b8"},"_deposit":{"created_by":1,"id":"54497","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"54497"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00054497","sets":["2"]},"author_link":["556640","556639","556646","556636","556637","556634","556635","556642","556644","556647","556645","556638","556643","556641"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"S1","bibliographicPageEnd":"i136","bibliographicPageStart":"i135","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose\nThe aim of this study was to clear any specific LETs cause change in skin reaction.  We irradiated mice feet with mono-energetic and SOBP carbon ions, to obtain dose response of early skin reaction at different LETs.\nMaterials and methods \nMice\nC3H/HeMsNrsf female mice aged 4 months old were used for this study. The animals were produced and maintained in specific pathogen-free (SPF) facilities. \nIrradiation \nThe mice right hind legs received daily fractionated irradiation ranged from single to 6 fractions.  Carbon ions (12C6+) were accelerated by the HIMAC synchrotron to 290 MeV/u. Irradiation was conducted using horizontal carbon-ion beams with a dose rate of ~3 Gy/min. We chose the LETs at entrance of plateau (20keV/μm) and the SOBP (proximal:40keV/μm, middle:45keV/μm, distal:60keV/μm, distal-end:80keV/μm). The reference beam was 137Cs γ-rays with a dose rate of 1.2 Gy/min. \nSkin reaction\nSkin reaction of the irradiated legs were scored every other day, between the14th and 35th post irradiation days. Our scoring scale consisted of 7 steps, ranging from 0.5 to 3.5.(1) The skin score analyzed a result by the method that  described by Ando.(2) The Fe-plot proposed Douglas and Fowler was used as a multifraction linear quadratic model. A plot between the reciprocal of the isoeffect dose and the dose per fraction resulted in a straight line. \nResults \nRequired isoeffect total dose increased linearly with the fraction numbers on a semi-logarithmic chart at LET 20- 60keV/µm SOBP beam. The isoeffect total dose decreased with increase of the LET. However, no increases of isoeffect total dose were observed at few fractionations at 80keV/µm. (data not shown) Using an Fe-plot, we analyzed the isoeffect total dose to evaluate the dependence on Carbon beam, or γ-ray. When I irradiate it by γ-ray, an Fe-plot shows linearly. But, irradiated by Carbon beam, an Fe-plot bent at low fractions. (Fig.1)\nConclusion\nThe LQ-model based Fe-plot could not fit skin reaction at few fractions at high-LET.","subitem_description_type":"Abstract"}]},"item_10003_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"oxford university press"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鵜澤, 玲子"}],"nameIdentifiers":[{"nameIdentifier":"556634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山, 亮一"}],"nameIdentifiers":[{"nameIdentifier":"556635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 孔貴"}],"nameIdentifiers":[{"nameIdentifier":"556636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"幸田, 華奈"}],"nameIdentifiers":[{"nameIdentifier":"556637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 幸子"}],"nameIdentifiers":[{"nameIdentifier":"556638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"556639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"556640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"幸田 華奈","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556647","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Fractionated Irradiation of Carbon Beam and the Isoeffect Dose on Acute Reaction of Skin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fractionated Irradiation of Carbon Beam and the Isoeffect Dose on Acute Reaction of Skin"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-20"},"publish_date":"2014-05-20","publish_status":"0","recid":"54497","relation_version_is_last":true,"title":["Fractionated Irradiation of Carbon Beam and the Isoeffect Dose on Acute Reaction of Skin"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:00:13.719183+00:00"}