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Preparation and MR Imaging of Giant Vesicles Containing Superparamagnetic Iron Oxide for Cell-Tracking MRI Probe
https://repo.qst.go.jp/records/54472
https://repo.qst.go.jp/records/54472d40d1b29-cab7-4a4f-b707-f6f8af01fb76
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-13 | |||||
| タイトル | ||||||
| タイトル | Preparation and MR Imaging of Giant Vesicles Containing Superparamagnetic Iron Oxide for Cell-Tracking MRI Probe | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Toyota, Taro
× Toyota, Taro× Ohguri, Naoto× Maruyama, Kouichi× Masanori, Fujinami× Saga, Tsuneo× Aoki, Ichio× 豊田 太郎× 大栗 直人× 丸山 耕一× 佐賀 恒夫× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Superparamagnetic iron oxide (SPIO) is a promising candidate for the development of smart and functional probes for cell-tracking systems. However, larger SPIO particles (>1 μm)[1] are not degraded but remain permanently in the cells and may induce long-term toxicity or change the function of the labeled cells. The use of smaller SPIO particles, especially of the nanometer-sized SPIO particles that are currently used for cell tracking, results in loss of signal detectability,[2] as well as accumulation of the particles to a high density within cells, which may also be toxic to the cells. Therefore, we focused on encapsulation of SPIO nanoparticles at high number density into giant vesicles (GVs; diameter, >1 μm) providing SPIO-containing GVs (SPIO-GVs). The concept will be also applicable to be “switched off” contrast agents by means of various vesicle-destroying stimuli. | |||||
| 書誌情報 |
Proc. Intl. Soc. Mag. Reson. Med. 巻 21, p. 1872-1872, 発行日 2014-02 |
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