@inproceedings{oai:repo.qst.go.jp:00054472,
 author = {Toyota, Taro and Ohguri, Naoto and Maruyama, Kouichi and Masanori, Fujinami and Saga, Tsuneo and Aoki, Ichio and 豊田 太郎 and 大栗 直人 and 丸山 耕一 and 佐賀 恒夫 and 青木 伊知男},
 book = {Proc. Intl. Soc. Mag. Reson. Med.},
 month = {Feb},
 note = {Superparamagnetic iron oxide (SPIO) is a promising candidate for the development of smart and functional probes for cell-tracking systems. However, larger SPIO particles (>1 μm)[1] are not degraded but remain permanently in the cells and may induce long-term toxicity or change the function of the labeled cells. The use of smaller SPIO particles, especially of the nanometer-sized SPIO particles that are currently used for cell tracking, results in loss of signal detectability,[2] as well as accumulation of the particles to a high density within cells, which may also be toxic to the cells. Therefore, we focused on encapsulation of SPIO nanoparticles at high number density into giant vesicles (GVs; diameter, >1 μm) providing SPIO-containing GVs (SPIO-GVs). The concept will be also applicable to be “switched off” contrast agents by means of various vesicle-destroying stimuli.},
 pages = {1872--1872},
 title = {Preparation and MR Imaging of Giant Vesicles Containing Superparamagnetic Iron Oxide for Cell-Tracking MRI Probe},
 volume = {21},
 year = {2014}
}