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Carbon Ion Radiotherapy for Skull Base and Upper Cervical Spine Tumors
https://repo.qst.go.jp/records/54422
https://repo.qst.go.jp/records/54422ea4ff2d7-6f7d-4c56-a88e-9fcb8bedfcdf
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-12 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy for Skull Base and Upper Cervical Spine Tumors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
小藤, 昌志
× 小藤, 昌志× 長谷川, 安都佐× 高木, 亮× 伊川, 裕明× 辻井, 博彦× 鎌田, 正× 小藤 昌志× 長谷川 安都佐× 高木 亮× 伊川 裕明× 辻井 博彦× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract Purpose: To estimate the toxicity and efficacy of carbon ion radiotherapy for skull base and upper cervical spine tumors. Patients and Methods: A phase I dose escalation study for skull base and upper cervical spine tumors was initiated in April 1997. The patients were treated with 16 fractions over four weeks, with a total dose of 48.0, 52.8, 57.6, or 60.8 Gy equivalents (GyE). In April 2004, a phase II study was initiated with an irradiation schedule of 60.8 GyE in 16 fractions over four weeks. There were 84 patients included in the analysis. Histologically, 51 patients had chordoma, 15 chondrosarcoma, nine olfactory neuroblastoma, seven meningioma and two had other types. The patients were treated with a dose of 48.0 GyE (four patients), 52.8 GyE (six patients), 57.6 GyE (nine patients) or 60.8 GyE (65 patients). Results: The follow-up periods ranged from four to 179 months, with a median period of 62 months. The five-year local control and overall survival rates for all patients were 86% and 85%, respectively. The five-year local control and overall survival rates for chordoma patients were 87% and 90%, respectively. At the time of the analysis, there was no evidence of any serious acute (Grade ≥ 4) reactions. Regarding late reactions, a grade 4 brain injury developed in one patient and a grade 4 optic nerve neuropathy developed in one patient. Conclusion: A carbon ion dose of 60.8 GyE in 16 fractions was effective and safe for the treatment of skull base and upper cervical spine tumors. |
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| 書誌情報 |
NIRS＆MedAustron Joint Symposium on Carbon Ion Radiotherapy p. 13-18, 発行日 2013-12 |
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