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Efficacy and Safety of Short Course Carbon-ion Radiotherapy for Patients with Preoperative Pancreatic Cancer
https://repo.qst.go.jp/records/54396
https://repo.qst.go.jp/records/54396de09f6e1-e339-4135-b882-3267a9b1dea0
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-14 | |||||
| タイトル | ||||||
| タイトル | Efficacy and Safety of Short Course Carbon-ion Radiotherapy for Patients with Preoperative Pancreatic Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Makoto
× Shinoto, Makoto× Yamada, Shigeru× Yasuda, Shigeo× Imada, Hiroshi× Kamada, Tadashi× Tsujii, Hirohiko× 篠藤 誠× 山田 滋× 安田 茂雄× 今田 浩史× 鎌田 正× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose/Objective(s):Complete surgical resection is the only curative treatment for pancreatic cancer. Even if a curative resection is performed, the disease usually recurs, and the half of the failure pattern is local recurrence. We examined the effect of short course preoperative carbon-ion radiotherapy (CIRT) in terms of reducing the rate of local recurrence in patients undergoing resection for adenocarcinoma of the pancreas. Materials/Methods: Patients with radiographically resectable pancreatic cancer were enrolled from October 2003 to July 2010. Eligibility included no CT involvement of celiac artery or SMA; adequate renal, hepatic and hematopoietic function; and ECOG PS 0-2. CIRT was given once daily, 4 days a week, for a fixed 8 fractions in 2 weeks. The dose was set to 30.0GyE and escalated to 36.8GyE at 5% increments with 5 levels. Treatment volumes included the location of the primary tumor and regional lymph nodes and retroperitoneal area. Surgery was performed 2-4 weeks after completion of CIRT. Results: Twenty-eight patients were enrolled on study. Twenty-five patients are eligible for this analysis. Five patients were treated at each of dose levels 1-2. Three patients were at dose level 3. Six patients were at each of dose levels 4-5. Twenty-one patients (84%) underwent resection. Reasons for no resections were: metastatic disease-3 and refusal-1 those were at dose levels 1-2. Although grade 3/4 toxicities were noted in 2 patients (liver abscess-1, PV thrombus-1), both of them were unrelated directly to CIRT. Median follow-up time is 13.9 months (range, 3.2-73.1). There has been on local failure in postoperative patients. Metastatic failure has occurred in 17 out of 25 patients (68%). Five-year survival rates in all patients and postoperative patients are 39% and 48%, respectively. Conclusions: Short course preoperative CIRT seems to be a safe and effective modality in the management of resectable pancreatic cancer, providing satisfactory local control and offering a survival advantage without unacceptable morbidity. |
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| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 82, 号 2, p. S331, 発行日 2011 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
