{"created":"2023-05-15T14:39:36.404232+00:00","id":54396,"links":{},"metadata":{"_buckets":{"deposit":"aa8db35a-1e59-4374-a09d-fbb5d3c54a32"},"_deposit":{"created_by":1,"id":"54396","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"54396"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00054396","sets":["2"]},"author_link":["555624","555621","555623","555622","555628","555630","555627","555631","555632","555625","555626","555629"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"S331","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose/Objective(s):Complete surgical resection is the only curative treatment for pancreatic cancer. Even if a curative resection is performed, the disease usually recurs, and the half of the failure pattern is local recurrence. We examined the effect of short course preoperative carbon-ion radiotherapy (CIRT) in terms of reducing the rate of local recurrence in patients undergoing resection for adenocarcinoma of the pancreas.\nMaterials/Methods: Patients with radiographically resectable pancreatic cancer were enrolled from October 2003 to July 2010. Eligibility included no CT involvement of celiac artery or SMA; adequate renal, hepatic and hematopoietic function; and ECOG PS 0-2. CIRT was given once daily, 4 days a week, for a fixed 8 fractions in 2 weeks. The dose was set to 30.0GyE and escalated to 36.8GyE at 5% increments with 5 levels. Treatment volumes included the location of the primary tumor and regional lymph nodes and retroperitoneal area. Surgery was performed 2-4 weeks after completion of CIRT.\nResults: Twenty-eight patients were enrolled on study. Twenty-five patients are eligible for this analysis. Five patients were treated at each of dose levels 1-2. Three patients were at dose level 3. Six patients were at each of dose levels 4-5. Twenty-one patients (84%) underwent resection. Reasons for no resections were: metastatic disease-3 and refusal-1 those were at dose levels 1-2. Although grade 3/4 toxicities were noted in 2 patients (liver abscess-1, PV thrombus-1), both of them were unrelated directly to CIRT. Median follow-up time is 13.9 months (range, 3.2-73.1). There has been on local failure in postoperative patients. Metastatic failure has occurred in 17 out of 25 patients (68%). Five-year survival rates in all patients and postoperative patients are 39% and 48%, respectively.\nConclusions: Short course preoperative CIRT seems to be a safe and effective modality in the management of resectable pancreatic cancer, providing satisfactory local control and offering a survival advantage without unacceptable morbidity.","subitem_description_type":"Abstract"}]},"item_10003_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shinoto, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"555621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"555622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"555623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imada, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"555624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"555625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"555626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠藤 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今田 浩史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555632","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Efficacy  and  Safety of Short Course Carbon-ion Radiotherapy for Patients with Preoperative Pancreatic Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficacy  and  Safety of Short Course Carbon-ion Radiotherapy for Patients with Preoperative Pancreatic Cancer"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-14"},"publish_date":"2013-11-14","publish_status":"0","recid":"54396","relation_version_is_last":true,"title":["Efficacy  and  Safety of Short Course Carbon-ion Radiotherapy for Patients with Preoperative Pancreatic Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:01:26.099252+00:00"}