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Carbon Ion Radiotherapy for Liver Cancer
https://repo.qst.go.jp/records/54388
https://repo.qst.go.jp/records/54388e9da8f75-0cd3-4b1d-81c3-7feddfb10c90
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-14 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy for Liver Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imada, Hiroshi
× Imada, Hiroshi× Yasuda, Shigeo× Yamada, Shigeru× Shinoto, Makoto× Oonishi, Kazuhiko× Endo, Satoshi× Kamada, Tadashi× Tsujii, Hirohiko× 今田 浩史× 安田 茂雄× 山田 滋× 篠藤 誠× 大西 和彦× 遠藤 悟史× 鎌田 正× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A trial of carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) was first conducted in April 1995 at the National Institute of Radiological Sciences (NIRS) in Japan. A total of 193 patients with HCC were enrolled in this clinical trial. In the first and second phase I/II clinical trials, dose escalation studies were carried out in incremental steps of 10%, resulting in the confirmation of both the safety and efficacy of short-course regimens of 12, 8, and 4 fractions. Based on the results, a phase II clinical study with fixed fractionation, that is, 52.8 GyE/4 fractions, was performed. A total of 47 patients were treated during this phase II study, which resulted in low toxicity and attained a high local control rate (96%) for 5 years after treatment. The last clinical study was conducted from April 2003 to August 2005, with a more hypofractionated regimen of 2 fractions/2 days, in which 36 patients were safely treated within a dose escalation range from 32.0 GyE to 38.8 GyE. The 2-fraction therapy protocol is continuing under the license of Highly Advanced Medical Technology. There have been no therapy-related deaths and no severe adverse events. We conclude that, because of the low toxicity and high local control rate, C-ion RT is a promising new, radical, and minimally invasive therapeutic option for HCC. | |||||
| 書誌情報 |
NIRS-ETOILE Joint Symposium on Carbon Ion Radiotherapy 巻 2, 号 NIRS-M-243, p. 46-53, 発行日 2011-11 |
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| 出版者 | ||||||
| 出版者 | National Institute of Radiological Sciences | |||||
