{"created":"2023-05-15T14:39:36.050757+00:00","id":54388,"links":{},"metadata":{"_buckets":{"deposit":"2849ddcd-9402-4c7e-883e-81512af5bd3b"},"_deposit":{"created_by":1,"id":"54388","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"54388"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00054388","sets":["2"]},"author_link":["555557","555560","555561","555554","555556","555549","555548","555552","555547","555553","555555","555551","555559","555558","555562","555550"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"NIRS-M-243","bibliographicPageEnd":"53","bibliographicPageStart":"46","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"NIRS-ETOILE Joint Symposium on Carbon Ion Radiotherapy"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A trial of carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) was first conducted in April 1995 at the National Institute of Radiological Sciences (NIRS) in Japan. A total of 193 patients with HCC were enrolled in this clinical trial. In the first and second phase I/II clinical trials, dose escalation studies were carried out in incremental steps of 10%, resulting in the confirmation of both the safety and efficacy of short-course regimens of 12, 8, and 4 fractions. Based on the results, a phase II clinical study with fixed fractionation, that is, 52.8 GyE/4 fractions, was performed. A total of 47 patients were treated during this phase II study, which resulted in low toxicity and attained a high local control rate (96%) for 5 years after treatment. The last clinical study was conducted from April 2003 to August 2005, with a more hypofractionated regimen of 2 fractions/2 days, in which 36 patients were safely treated within a dose escalation range from 32.0 GyE to 38.8 GyE. The 2-fraction therapy protocol is continuing under the license of Highly Advanced Medical Technology. There have been no therapy-related deaths and no severe adverse events. We conclude that, because of the low toxicity and high local control rate, C-ion RT is a promising new, radical, and minimally invasive therapeutic option for HCC.","subitem_description_type":"Abstract"}]},"item_10003_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Institute of Radiological Sciences"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imada, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"555547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"555548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"555549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"555550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oonishi, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"555551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"555552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"555553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"555554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今田 浩史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠藤 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 和彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤 悟史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555562","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Carbon Ion Radiotherapy for Liver Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon Ion Radiotherapy for Liver Cancer"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-14"},"publish_date":"2013-11-14","publish_status":"0","recid":"54388","relation_version_is_last":true,"title":["Carbon Ion Radiotherapy for Liver Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:01:31.634654+00:00"}