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Radiobiology of Chordoma Cells
https://repo.qst.go.jp/records/54291
https://repo.qst.go.jp/records/5429194e19f79-f722-4797-b4fa-5a597d6534c2
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-30 | |||||
| タイトル | ||||||
| タイトル | Radiobiology of Chordoma Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kato, Takamitsu
× Kato, Takamitsu× Tsuda, Akihisa× Uesaka, Mitsuru× Fujimori, Akira× Kamada, Tadashi× Tsujii, Hirohiko× Okayasu, Ryuichi× 加藤 宝光× 津田 晃久× 上坂 充× 藤森 亮× 鎌田 正× 辻井 博彦× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chordoma, a rare bone tumor, has been treated with surgery and/or radiation. However, only limited characterizations of chordoma cells are available due to the extremely long doubling time. To study the cell biology of chordoma, we derived and characterized a cell line with a shorter doubling time from the only available chordoma line U-CH1. After isolating a clone of U-CH1 cells with a short doubling time (U-CH1-N), cell growth, cell cycle distribution, DNA content, chromosome number, p53 status, and cell survival were examined after X-rays, heavy ions, camptothecin, mitomycin C, cisplatin and bleomycin. These data were compared with those of HeLa (cervical cancer) and U87-MG (glioblastoma) cells. The cell doubling times for HeLa, U87-MG and U-CH1-N were approximately 18 h, 24 h and 3 days respectively. Heavy ion irradiation killed all three lines more efficiently than x-rays. Relative biological effectiveness (RBE) at 10% survival for UCH-1-N was about 2.5 for 70keV/microm carbon and 4 for 200keV/microm iron ions. Among four chemicals, bleomycin showed the most marked cytotoxic effect on U-CH1-N. Our data provide the first chronological cell survival information using cells of chordoma origin and help explain the successful chordoma treatment by heavy ions. | |||||
| 書誌情報 |
National Institute of Radiological Sciences Annual Report p. 1-6, 発行日 2010-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-5956 | |||||
