{"created":"2023-05-15T14:39:31.766896+00:00","id":54291,"links":{},"metadata":{"_buckets":{"deposit":"a72789de-cdd5-48b4-8288-f9a3d727bd21"},"_deposit":{"created_by":1,"id":"54291","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"54291"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00054291","sets":["2"]},"author_link":["554517","554510","554520","554513","554509","554511","554512","554508","554514","554516","554521","554519","554515","554518"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"National Institute of Radiological Sciences Annual Report"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chordoma, a rare bone tumor, has been treated with surgery and/or radiation. However, only limited characterizations of chordoma cells are available due to the extremely long doubling time. To study the cell biology of chordoma, we derived and characterized a cell line with a shorter doubling time from the only available chordoma line U-CH1. After isolating a clone of U-CH1 cells with a short doubling time (U-CH1-N), cell growth, cell cycle distribution, DNA content, chromosome number, p53 status, and cell survival were examined after X-rays, heavy ions, camptothecin, mitomycin C, cisplatin and bleomycin. These data were compared with those of HeLa (cervical cancer) and U87-MG (glioblastoma) cells. The cell doubling times for HeLa, U87-MG and U-CH1-N were approximately 18 h, 24 h and 3 days respectively. Heavy ion irradiation killed all three lines more efficiently than x-rays. Relative biological effectiveness (RBE) at 10% survival for UCH-1-N was about 2.5 for 70keV/microm carbon and 4 for 200keV/microm iron ions. Among four chemicals, bleomycin showed the most marked cytotoxic effect on U-CH1-N. Our data provide the first chronological cell survival information using cells of chordoma origin and help explain the successful chordoma treatment by heavy ions.","subitem_description_type":"Abstract"}]},"item_10003_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-5956","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Takamitsu"}],"nameIdentifiers":[{"nameIdentifier":"554508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuda, Akihisa"}],"nameIdentifiers":[{"nameIdentifier":"554509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uesaka, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"554510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimori, Akira"}],"nameIdentifiers":[{"nameIdentifier":"554511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"554512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"554513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"554514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 宝光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"津田 晃久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上坂 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 亮","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554519","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554520","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554521","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Radiobiology of Chordoma Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiobiology of Chordoma Cells"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-05-30"},"publish_date":"2011-05-30","publish_status":"0","recid":"54291","relation_version_is_last":true,"title":["Radiobiology of Chordoma Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:02:40.278957+00:00"}