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Clinical Results of Carbon Ion Radiotherapy for Lymph Node Recurrence from Resected Colorectal Cancer
https://repo.qst.go.jp/records/54272
https://repo.qst.go.jp/records/54272ac2e692a-d72c-4130-b2e4-a458864e2530
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-14 | |||||
| タイトル | ||||||
| タイトル | Clinical Results of Carbon Ion Radiotherapy for Lymph Node Recurrence from Resected Colorectal Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Makoto
× Shinoto, Makoto× Yamada, Shigeru× Yasuda, Shigeo× Imada, Hiroshi× Kamada, Tadashi× Tsujii, Hirohiko× 篠藤 誠× 山田 滋× 安田 茂雄× 今田 浩史× 鎌田 正× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose/Objective(s) To evaluate the efficacy and complication of carbon ion radiotherapy in treating patients affected by lymph node recurrence from resected colorectal cancer. Materials/Methods Between December 2004 and December 2009, a total of 26 patients with 34 lymph node recurrences from resected colorectal cancer were treated with carbon ion radiotherapy. Lymph node recurrence from colorectal cancer without distant metastasis was confirmed by CT, MRI, and carbon-11 methionine positron emission tomography findings. The subsite distribution was paraaortic area, 59% (n = 20); iliac, 26% (n = 9); mediastinal, 9% (n = 3); inguinal, 3% (n = 1); and aortoiliac, 3% (n = 1). Twenty-one of 26 patients had undergone multimodality therapy for locoregional and/or metastatic recurrence. The median age was 55 years (range, 38-85). The doses were escalated from 48 GyE to 52.8 GyE and were delivered in 12 fractions/3weeks. The median follow-up period was 16.8 months. Results All patients completed the scheduled treatment course. No patient experienced acute or late morbidity of grade 3 or higher. Tumor response was evaluated in 34 lesions. Complete response (CR) was observed in 14 lesions and partial response (PR) in 13. Two lesions remained stable disease. The overall tumor response rate (CR+PR) was 79%. Remarkable anti-tumor effects were observed. The local control rates were 91% and 72% at 1 year and at 3 years, respectively. There is no local recurrence in the lesions receiving 50.4 GyE or more. The overall survival rates were 90% and 62% at 1 year and at 3 years, respectively. Conclusions Carbon ion radiotherapy seems to be a safe and effective modality in the management of lymph node recurrence from resected colorectal cancer, providing good local control and offering a survival advantage without unacceptable morbidity. |
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| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 78, 号 3 supplement, p. S308-S308, 発行日 2010-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
