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Carbon Ion Radiotherapy for Prostate Cancer
https://repo.qst.go.jp/records/54206
https://repo.qst.go.jp/records/54206f80a3869-4e9b-450e-86d7-0ec2b0d804c7
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-05 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy for Prostate Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuji, Hiroshi
× Tsuji, Hiroshi× Okada, Tohru× Sugahara, Shinji× Kato, Hiroyuki× Ishikawa, Hitoshi× Kamada, Tadashi× Mizoe, Junetsu× Kanai, Tatsuaki× Tsujii, Hirohiko× 辻 比呂志× 岡田 徹× 菅原 信二× 加藤 弘之× 石川 仁× 鎌田 正× 溝江 純悦× 金井 達明× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Analysis on the results of hypofractionated conformal carbon ion radiotherapy (C-ion RT) for localized prostate cancer was performed, with regard to normal tissue morbidity, biochemical relapse-free rate (bNED), and patient survival. Methods and Materials: Seven hundreds and forty prostate cancer patients who received C-ion RT established through two preceding dose-escalation studies were analyzed in regard to toxicity, survival, and bNED. Results: Concerning radiation morbidity, no grade 3 or higher toxicities were observed either in the rectum or genitourinary system (GU), and incidences of grade 2 rectum and GU morbidity were only 1.9% and 4.8%, respectively. Incidence of late GU toxicity in the patients treated with C-ion RT of 16 fractions was lower than that of 20 fractions. Overall bNED at 5 years was 90.2%, with only four local recurrences. The bNED of the C-ion RT of 16 fractions was comparable to that of 20 fractions. Gleason's score, T-stage, and initial PSA were significant prognostic factors for bNED, and T-stage and initial PSA were also significant prognostic factors for overall survival rate. The duration of hormonal therapy also had an impact on biochemical control in high-risk patients, but it appeared possible to apply C-ion RT with short-course hormonal therapy to intermediate-risk patients. Conclusion: C-ion RT with the established dose fractionation regimen yielded satisfactory bNED with very few local recurrences, and with minimal morbidity. C-ion RT of 16 fractions could offer even lower incidence of GU toxicity than that of 20 fractions. | |||||
| 書誌情報 |
NIRS-IMP Joint Symposium on Carbon Ion Therapy 巻 NIRS-M-225, p. 75-82, 発行日 2009-08 |
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| 出版者 | ||||||
| 出版者 | National Institute of Radiological Science | |||||
