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Effects of X-irradiation on proliferation and maintenance of mouse embryonic stem cell-derived neural stem cells
https://repo.qst.go.jp/records/54163
https://repo.qst.go.jp/records/541638e6d9948-82a9-4b09-9b40-9b2ff062a476
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-15 | |||||
| タイトル | ||||||
| タイトル | Effects of X-irradiation on proliferation and maintenance of mouse embryonic stem cell-derived neural stem cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Isono, Mayu
× Isono, Mayu× Tanabe, Toshiaki× Otsu, Masahiro× Ohtani, Hiroki× Fukushi, Masahiro× Nakayama, Takashi× Inoue, Nobuo× 磯野 真由 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation exposure during the fetal period leads to disturbances in development of the brain and can induce microcephaly. It suggests that X-irradiation may affect proliferation of the neural stem cells during early neural development. Here we investigated the effects of the irradiation on the neural stem cells, prepared from mouse embryonic stem (ES) cells by the Neural Stem Sphere (NSS) method. The proliferation of the neural stem cells cultured with fibroblast growth factor-2 (FGF-2) was dose-dependently inhibited by X-irradiation. Although X-irradiation also induced process elongation of the cells in a dose-dependent manner, gene expression of the marker genes for the neural stem cells, nestin, musashi-1, was maintained. This work was partly supported by a grant of LRI by JCIA and Selective Research Fund of Tokyo Metropolitan University. | |||||
| 書誌情報 |
Neuroscience Research 巻 61, p. s130-s130, 発行日 2008-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0168-0102 | |||||
