@inproceedings{oai:repo.qst.go.jp:00054163,
 author = {Isono, Mayu and Tanabe, Toshiaki and Otsu, Masahiro and Ohtani, Hiroki and Fukushi, Masahiro and Nakayama, Takashi and Inoue, Nobuo and 磯野 真由},
 book = {Neuroscience Research},
 month = {Sep},
 note = {Radiation exposure during the fetal period leads to disturbances in development of the brain and can induce microcephaly. It suggests that X-irradiation may affect proliferation of the neural stem cells during early neural development. Here we investigated the effects of the irradiation on the neural stem cells, prepared from mouse embryonic stem (ES) cells by the Neural Stem Sphere (NSS) method. The proliferation of the neural stem cells cultured with fibroblast growth factor-2 (FGF-2) was dose-dependently inhibited by X-irradiation. Although X-irradiation also induced process elongation of the cells in a dose-dependent manner, gene expression of the marker genes for the neural stem cells, nestin, musashi-1, was maintained. This work was partly supported by a grant of LRI by JCIA and Selective Research Fund of Tokyo Metropolitan University.},
 pages = {s130--s130},
 title = {Effects of X-irradiation on proliferation and maintenance of mouse embryonic stem cell-derived neural stem cells},
 volume = {61},
 year = {2008}
}