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Significance of Error-avoiding Mechanisms for Oxidative DNA Damage in Carcinogenesis
https://repo.qst.go.jp/records/54088
https://repo.qst.go.jp/records/54088e39cd504-6d93-452d-8726-dd6d41156493
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-01-06 | |||||
| タイトル | ||||||
| タイトル | Significance of Error-avoiding Mechanisms for Oxidative DNA Damage in Carcinogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuzuki, Teruhisa
× Tsuzuki, Teruhisa× Isoda, Takuro× Piao, J× Yamauchi, Kazumi× Egashira, Akinori× Sakamoto, Katsumi× Kura, Shinobu× Nakabeppu, Yusaku× Nakatsu, Yoshimichi× 山内 一己 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Oxygen radicals are produced through normal cellular metabolism, and formation of such radicals is further enhanced by ionizing radiation and by various chemicals. Among various classes of oxidative DNA damage, 8-oxo-7,8-dihydroguanine (8-oxoG) is the most abundant, and appears to play important roles in mutagenesis and carcinogenesis. We have focused on following the two enzymes. MTH1 protein hydrolyzes 8-oxo-dGTP to monophosphate in the nucleotide pool, thereby preventing occurrence of transversion mutations. On the other hand, MUTYH protein, having adenine/2-hydroxyadenine DNA glycosylase activity, is expected to prevent G:C to T:A transversions, by excising adenine from G:A mismatches induced by 8-oxoG and 2-OH-A. To analyze the function of the mammalian MTH1 and MUTYH proteins in vivo, we established gene-knockout mice for these two enzymes, and investigated spontaneous tumorigenesis as well as mutagenesis. | |||||
| 書誌情報 |
9th European Biological Inorganic Chemistry Conference : EUROBIC 9 : 2-6 September, 2008 Wroclaw, Poland p. 7-14, 発行日 2008-09 |
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| 出版者 | ||||||
| 出版者 | Medimond | |||||
| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 978-8-8758-7463 | |||||
