{"created":"2023-05-15T14:39:22.767454+00:00","id":54088,"links":{},"metadata":{"_buckets":{"deposit":"85c79f23-b1c9-40d2-a344-c9e75ed1d2df"},"_deposit":{"created_by":1,"id":"54088","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"54088"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00054088","sets":["2"]},"author_link":["552085","552086","552090","552084","552087","552089","552083","552092","552091","552088"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"14","bibliographicPageStart":"7","bibliographic_titles":[{"bibliographic_title":"9th European Biological Inorganic Chemistry Conference : EUROBIC 9 : 2-6 September, 2008 Wroclaw, Poland"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oxygen radicals are produced through normal cellular metabolism, and formation of such radicals is further enhanced by ionizing radiation and by various chemicals. Among various classes of oxidative DNA damage, 8-oxo-7,8-dihydroguanine (8-oxoG) is the most abundant, and appears to play important roles in mutagenesis and carcinogenesis. We have focused on following the two enzymes. MTH1 protein hydrolyzes 8-oxo-dGTP to monophosphate in the nucleotide pool, thereby preventing occurrence of transversion mutations. On the other hand, MUTYH protein, having adenine/2-hydroxyadenine DNA glycosylase activity, is expected to prevent G:C to T:A transversions, by excising adenine from G:A mismatches induced by 8-oxoG and 2-OH-A. To analyze the function of the mammalian MTH1 and MUTYH proteins in vivo, we established gene-knockout mice for these two enzymes, and investigated spontaneous tumorigenesis as well as mutagenesis.","subitem_description_type":"Abstract"}]},"item_10003_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Medimond"}]},"item_10003_relation_10":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"978-8-8758-7463","subitem_relation_type_select":"ISBN"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuzuki, Teruhisa"}],"nameIdentifiers":[{"nameIdentifier":"552083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isoda, Takuro"}],"nameIdentifiers":[{"nameIdentifier":"552084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Piao, J"}],"nameIdentifiers":[{"nameIdentifier":"552085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamauchi, Kazumi"}],"nameIdentifiers":[{"nameIdentifier":"552086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Egashira, Akinori"}],"nameIdentifiers":[{"nameIdentifier":"552087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakamoto, Katsumi"}],"nameIdentifiers":[{"nameIdentifier":"552088","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kura, Shinobu"}],"nameIdentifiers":[{"nameIdentifier":"552089","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakabeppu, Yusaku"}],"nameIdentifiers":[{"nameIdentifier":"552090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakatsu, Yoshimichi"}],"nameIdentifiers":[{"nameIdentifier":"552091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山内 一己","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"552092","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Significance of Error-avoiding Mechanisms for Oxidative DNA Damage in Carcinogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Significance of Error-avoiding Mechanisms for Oxidative DNA Damage in Carcinogenesis"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-06"},"publish_date":"2009-01-06","publish_status":"0","recid":"54088","relation_version_is_last":true,"title":["Significance of Error-avoiding Mechanisms for Oxidative DNA Damage in Carcinogenesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:05:01.859831+00:00"}