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Effects of Low Dose Particle Radiation to Mouse Neonatal Neurons in Culture
https://repo.qst.go.jp/records/53303
https://repo.qst.go.jp/records/533033976f6c0-c5e5-468b-9b48-fd89e280ecb5
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-01-24 | |||||
| タイトル | ||||||
| タイトル | Effects of Low Dose Particle Radiation to Mouse Neonatal Neurons in Culture | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
野島, 久美恵
× 野島, 久美恵× Ｖａｚｑｕｅｚ, Ｍａｒｃｅｌｏ Ｅ．× 長岡, 俊治× 野島 久美恵× 長岡 俊治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate effects of low dose heavy particle radiation to CNS system, we adopted mouse neonatal brain cells in culture being exposed to heavy ions generated by HIMAC at NIRS and BNL. The applied dose varied from 0.05Gy up to 2.0Gy. The subsequent biological effects were evaluated by an induction of apoptosis focusing on the dependencies of (1) the animal strains with different radiation sensitivities, and (2) LET with different nuclei. Of the three mouse strains, SCID, B6 and C3H, used for brain cell culture, SCID was the most sensitive and C3H the least sensitive to both X-ray and carbon ions (290 MeV/n) as evaluated by 10% apoptotic criterion. However, the least sensitivity differences among the strains were much smaller in case of carbon ion comparing to that of X-ray. Regarding the LET dependency, the neon (400 MeV/n) showed 1.4 fold difference for both C3H and B6 cells. Although a LET dependency was examined by using the most sensitive SCID cells, no significant difference was detected. | |||||
| 書誌情報 |
宇宙生物科学 巻 17, 号 3, p. 263-264, 発行日 2004-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-9201 | |||||
