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Inhibition of radiation-induced DNA-double strand break repair by various metal/metalloid compounds
https://repo.qst.go.jp/records/53129
https://repo.qst.go.jp/records/53129f48b8c02-ea8a-43e6-93d7-ff470b8bc8e6
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-10-20 | |||||
| タイトル | ||||||
| タイトル | Inhibition of radiation-induced DNA-double strand break repair by various metal/metalloid compounds | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahashi, Sentaro
× Takahashi, Sentaro× Okayasu, Ryuichi× Sato, Hiroshi× Kubota, Yoshihisa× S., Bedford Joel× 高橋 千太郎× 岡安 隆一× 佐藤 宏× 久保田 善久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order clarify the mechanism underlying the combined of effects of radiation and metals,we have studied the cytotoxicity and inhibition of radiation-induced DNA-double-strand-break(DNA-DSB)repair by various metals and metalloids.CHO cells were treated with NiCl2,NaAsO2,ZnCl2,CdCl2,CuCl2,and potassium antimony1 tartrate for 2h,and irradiated with gamma-rays at a dose of 40 Gy to induce DNA-DSB.Then,the degree of DNA-DSB was determined by an electrophoresis technique immediately after irradiation and following a 30-min repair period.The DNA-DSB repair was significantly inhibited by exposure to Ni,Cu,Zn,As,Sb,and Cd compounds at concentrations of 200,2.0,0.4,0.08,0.55,and 1.0 mM,respectively.At these concentrations,the cell viability determined by trypan blue dye exclusion was over 50% for all the chemicals,suggesting thet all of these compounds inhibited the repair of radiation-induced DNA-DSB at the concentrations where the acute cytotoxicity was relatively low.More significantly,the plationg efficiencies for As,Sb,and Zn compounds at these concentrations were higher than 10%,suggesting that these chemicals inhibited DNA-DSB repair at relatively low concentrations where of some of the cells sustained ability of proliferation. | |||||
| 書誌情報 |
Radiation and Homeostasis : Proceedings of the International Symposium of Radiation and Homeostasis, held in Kyoto, Japan, 13-16 July 2001(International Congress Series ; no. 1236) p. 327-330, 発行日 2002 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
