{"created":"2023-05-15T14:38:37.344481+00:00","id":53129,"links":{},"metadata":{"_buckets":{"deposit":"f4c0641b-06d3-4ceb-80c8-3147ea15a6af"},"_deposit":{"created_by":1,"id":"53129","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"53129"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00053129","sets":["2"]},"author_link":["542104","542101","542105","542108","542106","542100","542107","542102","542103"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"330","bibliographicPageStart":"327","bibliographic_titles":[{"bibliographic_title":"Radiation and Homeostasis : Proceedings of the International Symposium of Radiation and Homeostasis, held in Kyoto, Japan, 13-16 July 2001(International Congress Series ; no. 1236)"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order clarify the mechanism underlying the combined of effects of radiation and metals,we have studied the cytotoxicity and inhibition  of radiation-induced DNA-double-strand-break(DNA-DSB)repair by various metals and metalloids.CHO cells were treated with NiCl2,NaAsO2,ZnCl2,CdCl2,CuCl2,and potassium antimony1 tartrate for 2h,and irradiated with gamma-rays at a dose of 40 Gy to induce DNA-DSB.Then,the degree of DNA-DSB was determined by an electrophoresis technique immediately after irradiation and following a 30-min repair period.The DNA-DSB repair was significantly inhibited by exposure to Ni,Cu,Zn,As,Sb,and Cd compounds at concentrations of 200,2.0,0.4,0.08,0.55,and 1.0 mM,respectively.At these concentrations,the cell viability determined by trypan blue dye exclusion was over 50% for all the chemicals,suggesting thet all of these compounds inhibited the repair of radiation-induced DNA-DSB at the concentrations where the acute cytotoxicity was relatively low.More significantly,the plationg efficiencies for As,Sb,and Zn compounds at these concentrations were higher than 10%,suggesting that these chemicals inhibited DNA-DSB repair at relatively low concentrations where of some of the cells sustained ability of proliferation.","subitem_description_type":"Abstract"}]},"item_10003_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Sentaro"}],"nameIdentifiers":[{"nameIdentifier":"542100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"542101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"542102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Yoshihisa"}],"nameIdentifiers":[{"nameIdentifier":"542103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"S., Bedford Joel"}],"nameIdentifiers":[{"nameIdentifier":"542104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 千太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"542105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"542106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 宏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"542107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保田 善久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"542108","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Inhibition of radiation-induced DNA-double strand break repair by various metal/metalloid compounds","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of radiation-induced DNA-double strand break repair by various metal/metalloid compounds"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-10-20"},"publish_date":"2003-10-20","publish_status":"0","recid":"53129","relation_version_is_last":true,"title":["Inhibition of radiation-induced DNA-double strand break repair by various metal/metalloid compounds"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:16:08.938358+00:00"}