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Reactivity of Redox Sensitive Paramagnetic Nitroxyl Contrast Agents and Reactive Oxygen Species
https://repo.qst.go.jp/records/49394
https://repo.qst.go.jp/records/49394a13d43d9-c8c2-4967-8725-b9e1618a89e7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-08-15 | |||||
| タイトル | ||||||
| タイトル | Reactivity of Redox Sensitive Paramagnetic Nitroxyl Contrast Agents and Reactive Oxygen Species | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nyui, Minako
× Nyui, Minako× Nakanishi, Ikuo× Anzai, Kazunori× Ozawa, Toshihiko× Ken-ichiro, Matsumoto× Minako, Nyui× Ikuo, Nakanishi× Kazunori, Anzai× Toshihiko, Ozawa× Kenichiro, Matsumoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The reactivity of nitroxyl free radicals with reactive oxygen species (ROS) were compared. Here, 4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CmP) were tested as typical 6-membered and 5-membered ring nitroxyl compounds. The hydroxyl amin forms of the both nitroxyl radicals, i.e. TEMPOL-H and CmP-H, were also tested. Two free radical species of ROS, i.e. hydroxyl radical (•OH) and superoxide (O2•-), were subjected to a competition. •OH was generated by UV irradiation from an aqueous H2O2 solution (H2O2-UV system). O2•- was generated by a reaction of hypoxanthine and xanthine oxidase (HX-XO system). The amounts of generated ROS, i.e. •OH generated by the H2O2-UV system or the O2•- by the HX-XO system, were quantified by electron paramagnetic resonance (EPR) spin-trapping, and were adjusted to be similar. The time courses of one-electron oxidation of TEMPOL, CmP, TEMPOL-H, and CmP-H in each ROS generation system were observed and compared. TEMPOL was more oxidized in the HX-XO system than in the H2O2-UV system, while CmP was more oxidized in the H2O2-UV system than in the HX-XO system. The hydroxylamine form of nitroxyl radicals, i.e. TEMPOL-H and CmP-H, were similary oxidized eather in the H2O2-UV system or the HX-XO system, while the CmP-H was almost 3 times more oxidized compare to TEMPOL-H. | |||||
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 64, 号 1, p. 13-19, 発行日 2018-09 |
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| 出版者 | ||||||
| 出版者 | Society for Free Radical Research Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30705507 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3164/jcbn.17-135 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3164/jcbn.17-135 | |||||
