{"created":"2023-05-15T14:38:16.646362+00:00","id":49394,"links":{},"metadata":{"_buckets":{"deposit":"a9fabdd4-bdae-41b9-9a88-0d3fd4fc7388"},"_deposit":{"created_by":1,"id":"49394","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49394"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049394","sets":["1"]},"author_link":["1024984","1024985","1024987","1024980","1024988","1024979","1024986","1024982","1024983","1024981"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"13","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The reactivity of nitroxyl free radicals with reactive oxygen species (ROS) were compared. Here, 4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CmP) were tested as typical 6-membered and 5-membered ring nitroxyl compounds. The hydroxyl amin forms of the both nitroxyl radicals, i.e. TEMPOL-H and CmP-H, were also tested. Two free radical species of ROS, i.e. hydroxyl radical (•OH) and superoxide (O2•-), were subjected to a competition. •OH was generated by UV irradiation from an aqueous H2O2 solution (H2O2-UV system). O2•- was generated by a reaction of hypoxanthine and xanthine oxidase (HX-XO system). The amounts of generated ROS, i.e. •OH generated by the H2O2-UV system or the O2•- by the HX-XO system, were quantified by electron paramagnetic resonance (EPR) spin-trapping, and were adjusted to be similar. The time courses of one-electron oxidation of TEMPOL, CmP, TEMPOL-H, and CmP-H in each ROS generation system were observed and compared. TEMPOL was more oxidized in the HX-XO system than in the  H2O2-UV system, while CmP was more oxidized in the H2O2-UV system than in the HX-XO system. The hydroxylamine form of nitroxyl radicals, i.e. TEMPOL-H and CmP-H, were similary oxidized eather in the H2O2-UV system or the HX-XO system, while the CmP-H was almost 3 times more oxidized compare to TEMPOL-H.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Free Radical Research Japan"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30705507","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3164/jcbn.17-135","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.17-135","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0009","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nyui, Minako"}],"nameIdentifiers":[{"nameIdentifier":"1024979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"1024980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"1024981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"1024982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ken-ichiro, Matsumoto"}],"nameIdentifiers":[{"nameIdentifier":"1024983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minako, Nyui","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikuo, Nakanishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Anzai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshihiko, Ozawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenichiro, Matsumoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024988","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reactivity of Redox Sensitive Paramagnetic Nitroxyl Contrast Agents and Reactive Oxygen Species","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reactivity of Redox Sensitive Paramagnetic Nitroxyl Contrast Agents and Reactive Oxygen Species"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-08-15"},"publish_date":"2017-08-15","publish_status":"0","recid":"49394","relation_version_is_last":true,"title":["Reactivity of Redox Sensitive Paramagnetic Nitroxyl Contrast Agents and Reactive Oxygen Species"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:04:23.753191+00:00"}