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Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula
https://repo.qst.go.jp/records/49364
https://repo.qst.go.jp/records/493643f86ef48-2dcc-4be0-a038-7fa6f6ac145e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-26 | |||||
| タイトル | ||||||
| タイトル | Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Hitoshi
× Shinoto, Hitoshi× Shimada, Hitoshi× Yasumasa Kokubo× Tagai, Kenji× Niwa, Fumitoshi× Kitamura, Soichiro× Endo, Hironobu× Ono, Maiko× Kimura, Yasuyuki× Hirano, Shigeki× Mimuro, Maya× Ichise, Masanori× Sahara, Naruhiko× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto× Shinoto, Hitoshi× Shimada, Hitoshi× Tagai, Kenji× Niwa, Fumitoshi× Kitamura, Soichiro× Endo, Hironobu× Ono, Maiko× Kimura, Yasuyuki× Hirano, Shigeki× Ichise, Masanori× Sahara, Naruhiko× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | OBJECTIVE: To characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [11C]PBB3 as ligand. METHODS: This is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Thirteen healthy men (69 ± 6 years) participated as healthy controls (HCs). Dynamic PET scans were performed following injection of [11C]PBB3, and parametric PET images were generated by voxel-by-voxel calculation of binding potential (BP* ND) using a multilinear reference tissue model. [11C] Pittsburgh compound B (PiB) PET, MRI, and cognitive tests were also performed. RESULTS: A voxel-based comparison of [11C]PBB3 BP* ND illustrated PET-detectable tau deposition in the cerebral cortex and white matter, and pontine basis including the corticospinal tract in Kii ALS/PDC patients compared with HCs (uncorrected p < 0.05). Group-wise volume of interest analysis of [11C]PBB3 BP* ND images showed increased BP* ND in the hippocampus and in frontal and parietal white matters of Kii ALS/PDC patients relative to HCs (p < 0.05, Holm-Sidak multiple comparisons test). BP* ND in frontal, temporal, and parietal gray matters correlated with Mini-Mental State Examination scores in Kii ALS/PDC patients (p < 0.05). All Kii ALS/PDC patients were negative for [11C]PiB (β-amyloid) except one with marginal positivity. CONCLUSION: [11C]PBB3 PET visualized the characteristic topography of tau pathology in Kii ALS/PDC, corresponding to clinical phenotypes of this disease. |
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| 書誌情報 |
Neurology 巻 92, 号 2, p. e136-e147, 発行日 2018-12 |
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| 出版者 | ||||||
| 出版者 | American Academy of Neurology Publications | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0028-3878 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30530797 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1212/WNL.0000000000006736 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://n.neurology.org/content/92/2/e136 | |||||
