{"_buckets": {"deposit": "e38a95ae-d122-4ab7-a851-90940df011f1"}, "_deposit": {"created_by": 1, "id": "49364", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "49364"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00049364", "sets": ["1"]}, "author_link": ["864958", "864964", "864980", "864972", "864977", "864986", "864985", "864983", "864963", "864959", "864975", "864981", "864969", "864987", "864968", "864984", "864976", "864966", "864979", "864973", "864971", "864967", "864960", "864982", "864962", "864965", "864974", "864978", "864961", "864970"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "e147", "bibliographicPageStart": "e136", "bibliographicVolumeNumber": "92", "bibliographic_titles": [{"bibliographic_title": "Neurology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "OBJECTIVE: \n\nTo characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [11C]PBB3 as ligand.\n\nMETHODS: \n\nThis is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Thirteen healthy men (69 ± 6 years) participated as healthy controls (HCs). Dynamic PET scans were performed following injection of [11C]PBB3, and parametric PET images were generated by voxel-by-voxel calculation of binding potential (BP* ND) using a multilinear reference tissue model. [11C] Pittsburgh compound B (PiB) PET, MRI, and cognitive tests were also performed.\n\nRESULTS: \n\nA voxel-based comparison of [11C]PBB3 BP* ND illustrated PET-detectable tau deposition in the cerebral cortex and white matter, and pontine basis including the corticospinal tract in Kii ALS/PDC patients compared with HCs (uncorrected p \u003c 0.05). Group-wise volume of interest analysis of [11C]PBB3 BP* ND images showed increased BP* ND in the hippocampus and in frontal and parietal white matters of Kii ALS/PDC patients relative to HCs (p \u003c 0.05, Holm-Sidak multiple comparisons test). BP* ND in frontal, temporal, and parietal gray matters correlated with Mini-Mental State Examination scores in Kii ALS/PDC patients (p \u003c 0.05). All Kii ALS/PDC patients were negative for [11C]PiB (β-amyloid) except one with marginal positivity.\n\nCONCLUSION: \n\n[11C]PBB3 PET visualized the characteristic topography of tau pathology in Kii ALS/PDC, corresponding to clinical phenotypes of this disease.\n", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "American Academy of Neurology Publications"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "30530797 ", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1212/WNL.0000000000006736", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://n.neurology.org/content/92/2/e136", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0028-3878", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shinoto, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "864958", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "864959", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasumasa Kokubo"}], "nameIdentifiers": [{"nameIdentifier": "864960", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tagai, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "864961", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi"}], "nameIdentifiers": [{"nameIdentifier": "864962", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "864963", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "864964", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Maiko"}], "nameIdentifiers": [{"nameIdentifier": "864965", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "864966", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirano, Shigeki"}], "nameIdentifiers": [{"nameIdentifier": "864967", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mimuro, Maya"}], "nameIdentifiers": [{"nameIdentifier": "864968", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori"}], "nameIdentifiers": [{"nameIdentifier": "864969", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko"}], "nameIdentifiers": [{"nameIdentifier": "864970", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "864971", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "864972", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "864973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinoto, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tagai, Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Hironobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864979", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Maiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864981", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirano, Shigeki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864982", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864983", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864984", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864985", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864986", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864987", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/49364", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-12-26"}, "publish_date": "2018-12-26", "publish_status": "0", "recid": "49364", "relation": {}, "relation_version_is_last": true, "title": ["Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula"], "weko_shared_id": -1}