{"created":"2023-05-15T14:38:15.135499+00:00","id":49364,"links":{},"metadata":{"_buckets":{"deposit":"e38a95ae-d122-4ab7-a851-90940df011f1"},"_deposit":{"created_by":1,"id":"49364","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49364"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049364","sets":["1"]},"author_link":["864958","864964","864980","864972","864977","864986","864985","864983","864963","864959","864975","864981","864969","864987","864968","864984","864976","864966","864979","864973","864971","864967","864960","864982","864962","864965","864974","864978","864961","864970"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"e147","bibliographicPageStart":"e136","bibliographicVolumeNumber":"92","bibliographic_titles":[{"bibliographic_title":"Neurology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"OBJECTIVE: \n\nTo characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [11C]PBB3 as ligand.\n\nMETHODS: \n\nThis is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Thirteen healthy men (69 ± 6 years) participated as healthy controls (HCs). Dynamic PET scans were performed following injection of [11C]PBB3, and parametric PET images were generated by voxel-by-voxel calculation of binding potential (BP* ND) using a multilinear reference tissue model. [11C] Pittsburgh compound B (PiB) PET, MRI, and cognitive tests were also performed.\n\nRESULTS: \n\nA voxel-based comparison of [11C]PBB3 BP* ND illustrated PET-detectable tau deposition in the cerebral cortex and white matter, and pontine basis including the corticospinal tract in Kii ALS/PDC patients compared with HCs (uncorrected p < 0.05). Group-wise volume of interest analysis of [11C]PBB3 BP* ND images showed increased BP* ND in the hippocampus and in frontal and parietal white matters of Kii ALS/PDC patients relative to HCs (p < 0.05, Holm-Sidak multiple comparisons test). BP* ND in frontal, temporal, and parietal gray matters correlated with Mini-Mental State Examination scores in Kii ALS/PDC patients (p < 0.05). All Kii ALS/PDC patients were negative for [11C]PiB (β-amyloid) except one with marginal positivity.\n\nCONCLUSION: \n\n[11C]PBB3 PET visualized the characteristic topography of tau pathology in Kii ALS/PDC, corresponding to clinical phenotypes of this disease.\n","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Academy of Neurology Publications"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30530797 ","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1212/WNL.0000000000006736","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://n.neurology.org/content/92/2/e136","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0028-3878","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shinoto, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"864958","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"864959","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasumasa Kokubo"}],"nameIdentifiers":[{"nameIdentifier":"864960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tagai, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"864961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"864962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro"}],"nameIdentifiers":[{"nameIdentifier":"864963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Hironobu"}],"nameIdentifiers":[{"nameIdentifier":"864964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko"}],"nameIdentifiers":[{"nameIdentifier":"864965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"864966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"864967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimuro, Maya"}],"nameIdentifiers":[{"nameIdentifier":"864968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"864969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"864970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"864971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"864972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"864973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tagai, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Fumitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Hironobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"864987","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-12-26"},"publish_date":"2018-12-26","publish_status":"0","recid":"49364","relation_version_is_last":true,"title":["Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:59:34.187668+00:00"}