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Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells
https://repo.qst.go.jp/records/49343
https://repo.qst.go.jp/records/493432a5cba80-db98-40b7-8004-7b567ea1dd80
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-07-18 | |||||
| タイトル | ||||||
| タイトル | Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kobayashi, Alisa
× Kobayashi, Alisa× Konishi, Teruaki× Kobayashi, Alisa× Konishi, Teruaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study aimed to determine whether the radiation induced bystander effect (RIBE) is affected by the radiation quality. To mimic the different radiation qualities of the direct action (D) / indirect action (ID) ratio, A549 cells were exposed to X-rays, with either 100 mM of the radical scavenger, thio-urea (TU+), or null (TU-). Biological responses in irradiated and bystander cells were compared at equal lethal effects of a 6% survival dose, which was estimated from the survival curves to be 8 Gy and 5 Gy for TU+ and TU-, respectively. The cyclooxygenase-2 (COX-2) expression in TU- irradiated cells increased up to 8 hrs post-irradiation, before decreasing toward 24 hrs. The concentration of prostaglandin E2 (PGE2), a primary product of COX-2, and known as a secreted inducible factor of RIBE have increased over 3-fold compared with that in the control at 8 hrs post irradiation. Conversely, COX-2 expression and PGE2 production of TU+ irradiated cells were drastically suppressed. These results show that the larger D/ID suppressed COX-2 expression and PGE2 production in irradiated cells. However, in contrast to the irradiated cells, the COX-2 expression was equally observed in the TU- and TU+ co-cultured bystander cells, which shows the highest expression levels at 24hrs post-irradiation. Taken together, these findings demonstrate that radiation quality, such as the D/ID ratio may become an important factor in the alteration of signalling pathways involved in RIBE. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 59, 号 6, p. 754-759, 発行日 2018-07 |
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| 出版者 | ||||||
| 出版者 | OXFORD UNIVERSITY PRESS | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30124879 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rry065 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/jrr/advance-article/doi/10.1093/jrr/rry065/5073310 | |||||
