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Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences.
https://repo.qst.go.jp/records/49293
https://repo.qst.go.jp/records/4929365b9eca6-4997-4593-95d6-d402856600a0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-03 | |||||
| タイトル | ||||||
| タイトル | Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okada, Naohiro
× Okada, Naohiro× Yahata, Noriaki× Koshiyama, Daisuke× Morita, Kentaro× Sawada, Kingo× Kanata, Sho× Fujikawa, Shinya× Sugimoto, Noriko× Toriyama, Rie× Masaoka, Mio× Koike, Shinsuke× Araki, Tsuyoshi× Kano, Yukiko× Endo, Kaori× Yamasaki, Syudo× Ando, Shuntaro× Nishida, Atsushi× Mariko, Hiraiwa-Hasegawa× Kasai, Kiyoto× Yahata, Noriaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Subcortical structures may have an important role in the pathophysiology of psychosis. Our recent mega-analysis of structural magnetic resonance imaging (MRI) data has reported subcortical volumetric and lateralization alterations in chronic schizophrenia, including leftward asymmetric increases in pallidal volume. The question remains, however, whether these characteristics may represent vulnerability to the development of psychosis or whether they are epiphenomena caused by exposure to medication or illness chronicity. Subclinical psychotic experiences (SPEs) occur in some adolescents in the general population and increase the odds of developing psychosis in young adulthood. Investigations into the association between SPEs and MRI-measured volumes of subcortical structures in the general adolescent population would clarify the issue. Here, we collected structural MRI data in a subsample (10.5-13.3 years old) of a large-scale population-based cohort and explored subcortical volume and lateralization alterations related to SPEs (N = 203). Adolescents with SPEs demonstrated significant volumetric increases in the left hippocampus, right caudate, and right lateral ventricle, as well as a marginally significant increase in the left pallidum. Furthermore, adolescents with SPEs showed significantly more leftward laterality of pallidal volume than individuals without SPEs, which replicates our mega-analysis findings in chronic schizophrenia. We suggest that leftward asymmetries in pallidal volume already present in early adolescence may underlie the premorbid predisposition for developing psychosis in later life. | |||||
| 書誌情報 |
Translational psychiatry 巻 8, 号 1, p. 254, 発行日 2018-11 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2158-3188 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30487578 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41398-018-0312-6 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41398-018-0312-6 | |||||
