@article{oai:repo.qst.go.jp:00049293,
 author = {Okada, Naohiro and Yahata, Noriaki and Koshiyama, Daisuke and Morita, Kentaro and Sawada, Kingo and Kanata, Sho and Fujikawa, Shinya and Sugimoto, Noriko and Toriyama, Rie and Masaoka, Mio and Koike, Shinsuke and Araki, Tsuyoshi and Kano, Yukiko and Endo, Kaori and Yamasaki, Syudo and Ando, Shuntaro and Nishida, Atsushi and Mariko, Hiraiwa-Hasegawa and Kasai, Kiyoto and Yahata, Noriaki},
 issue = {1},
 journal = {Translational psychiatry},
 month = {Nov},
 note = {Subcortical structures may have an important role in the pathophysiology of psychosis. Our recent mega-analysis of structural magnetic resonance imaging (MRI) data has reported subcortical volumetric and lateralization alterations in chronic schizophrenia, including leftward asymmetric increases in pallidal volume. The question remains, however, whether these characteristics may represent vulnerability to the development of psychosis or whether they are epiphenomena caused by exposure to medication or illness chronicity. Subclinical psychotic experiences (SPEs) occur in some adolescents in the general population and increase the odds of developing psychosis in young adulthood. Investigations into the association between SPEs and MRI-measured volumes of subcortical structures in the general adolescent population would clarify the issue. Here, we collected structural MRI data in a subsample (10.5-13.3 years old) of a large-scale population-based cohort and explored subcortical volume and lateralization alterations related to SPEs (N = 203). Adolescents with SPEs demonstrated significant volumetric increases in the left hippocampus, right caudate, and right lateral ventricle, as well as a marginally significant increase in the left pallidum. Furthermore, adolescents with SPEs showed significantly more leftward laterality of pallidal volume than individuals without SPEs, which replicates our mega-analysis findings in chronic schizophrenia. We suggest that leftward asymmetries in pallidal volume already present in early adolescence may underlie the premorbid predisposition for developing psychosis in later life.},
 title = {Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences.},
 volume = {8},
 year = {2018}
}