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Detection of mRNA in mammalian cells with a Sprit Ribozyme Reporter
https://repo.qst.go.jp/records/49227
https://repo.qst.go.jp/records/49227cd5b295a-306f-47fb-85c3-bfdbd36c22a1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-31 | |||||
| タイトル | ||||||
| タイトル | Detection of mRNA in mammalian cells with a Sprit Ribozyme Reporter | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hasegawa, Sumitaka
× Hasegawa, Sumitaka× et.al× 長谷川 純崇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This communication describes a split RNA reporter strategy for sensing RNAs in mammalian cells. A Tetrahymena group I intron ribozyme reporter was split into two halves, and in the presence of the target RNA, the split reporter assembled into an active complex that trans-spliced and produced a reporter enzyme. We show that this split reporter can sense tumor suppressor p53 mutant mRNA in mammalian cells. This system may open up new avenues for detecting and imaging RNA molecules in vivo. | |||||
| 書誌情報 |
Chembiochem 巻 7, 号 6, p. 925-928, 発行日 2006-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1439-4227 | |||||
