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In vivo simultaneous imaging with 99mTc and 18F using a Compton camera
https://repo.qst.go.jp/records/49214
https://repo.qst.go.jp/records/49214a7537f50-46f5-48b3-b846-2ab2c931e18d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-22 | |||||
| タイトル | ||||||
| タイトル | In vivo simultaneous imaging with 99mTc and 18F using a Compton camera | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakai, Makoto
× Sakai, Makoto× Yamaguchi, Mitsutaka× Nagao, Yuuto× Kawachi, Naoki× Kikuchi, Mikiko× Torikai, (Gunma Univ.) Kota× Kamiya, (Gunma Univ.) Tomihiro× Takeda, (Univ. of Tokyo) Shin'ichiro× Watanabe, (JAXA) Shin× Takahashi, (Univ. of Tokyo) Tadayuki× Arakawa, Kazuo× Nakano, (Gunma Univ.) Takashi× 酒井 真理× 山口 充孝× 長尾 悠人× 河地 有木× 菊地 美貴子× 荒川 和夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have been developing a medical imaging technique using a Compton camera. This study evaluates the feasibility of clear imaging with 99mTc and 18F simultaneously, and demonstrates in vivo imaging with 99mTc and/or 18F. We used a Compton camera with silicon and cadmium telluride (Si/CdTe) semiconductors. We estimated the imaging performance of the Compton camera for 141 keV and 511 keV gamma rays from 99mTc and 22Na, respectively. Next, we simultaneously imaged 99mTc and 18F point sources to evaluate the cross-talk artifacts produced by a higher energy gamma-ray background. Then, in the in vivo experiments, three rats were injected with 99mTc-dimercaptosuccinic acid and/or 18F-fluorodeoxyglucose and imaged. The Compton images were compared with PET images. The rats were euthanized, and the activities in their organs were measured using a well counter. The energy resolution and spatial resolution were measured for the sources. No apparent cross-talk artifacts were observed in the practical-activity ratio (99mTc:18F = 1:16). We succeeded in imaging the distributions of 99mTc and 18F simultaneously, and the results were consistent with the PET images and well counter measurements. Our Si/CdTe Compton camera can thus work as a multi-tracer imager, covering various SPECT and PET probes, with less cross-talk artifacts in comparison to the conventional Anger cameras using a collimator. Our findings suggest the possibility of human trials. | |||||
| 書誌情報 |
Physics in Medicine & Biology 巻 63, 号 20, p. 205006-1-205006-12, 発行日 2018-10 |
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| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/1361-6560/aae1d1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://iopscience.iop.org/article/10.1088/1361-6560/aae1d1 | |||||
| 関連名称 | http://iopscience.iop.org/article/10.1088/1361-6560/aae1d1 | |||||
