@article{oai:repo.qst.go.jp:00049214,
 author = {Sakai, Makoto and Yamaguchi, Mitsutaka and Nagao, Yuuto and Kawachi, Naoki and Kikuchi, Mikiko and Torikai, (Gunma Univ.) Kota and Kamiya, (Gunma Univ.) Tomihiro and Takeda, (Univ. of Tokyo) Shin'ichiro and Watanabe, (JAXA) Shin and Takahashi, (Univ. of Tokyo) Tadayuki and Arakawa, Kazuo and Nakano, (Gunma Univ.) Takashi and 酒井 真理 and 山口 充孝 and 長尾 悠人 and 河地 有木 and 菊地 美貴子 and 荒川 和夫},
 issue = {20},
 journal = {Physics in Medicine & Biology},
 month = {Oct},
 note = {We have been developing a medical imaging technique using a Compton camera. This study evaluates the feasibility of clear imaging with 99mTc and 18F simultaneously, and demonstrates in vivo imaging with 99mTc and/or 18F. We used a Compton camera with silicon and cadmium telluride (Si/CdTe) semiconductors. We estimated the imaging performance of the Compton camera for 141 keV and 511 keV gamma rays from 99mTc and 22Na, respectively. Next, we simultaneously imaged 99mTc and 18F point sources to evaluate the cross-talk artifacts produced by a higher energy gamma-ray background. Then, in the in vivo experiments, three rats were injected with 99mTc-dimercaptosuccinic acid and/or 18F-fluorodeoxyglucose and imaged. The Compton images were compared with PET images. The rats were euthanized, and the activities in their organs were measured using a well counter. The energy resolution and spatial resolution were measured for the sources. No apparent cross-talk artifacts were observed in the practical-activity ratio (99mTc:18F = 1:16). We succeeded in imaging the distributions of 99mTc and 18F simultaneously, and the results were consistent with the PET images and well counter measurements. Our Si/CdTe Compton camera can thus work as a multi-tracer imager, covering various SPECT and PET probes, with less cross-talk artifacts in comparison to the conventional Anger cameras using a collimator. Our findings suggest the possibility of human trials.},
 pages = {205006-1--205006-12},
 title = {In vivo simultaneous imaging with 99mTc and 18F using a Compton camera},
 volume = {63},
 year = {2018}
}