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Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans
https://repo.qst.go.jp/records/49078
https://repo.qst.go.jp/records/49078545340c7-30d5-452d-a96e-cce4e2260ef7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-14 | |||||
| タイトル | ||||||
| タイトル | Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Takehito
× Ito, Takehito× Kimura, Yasuyuki× Seki, Chie× Ichise, Masanori× Yokokawa, Keita× Kawamura, Kazunori× Takahashi, Hidehiko× Higuchi, Makoto× Ming-Rong, Zhang× Suhara, Tetsuya× Yamada, Makiko× Ito, Takehito× Kimura, Yasuyuki× Seki, Chie× Ichise, Masanori× Yokokawa, Keita× Kawamura, Kazunori× Takahashi, Hidehiko× Higuchi, Makoto× Ming-Rong, Zhang× Suhara, Tetsuya× Yamada, Makiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cognitive functions such as working memory. However, the role of prefrontal H3 receptors in working memory has not yet been clarified. Therefore, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) techniques, we aimed to investigate the association between the neural activity of working memory and the density of H3 receptors in the prefrontal cortex. Findings Ten healthy volunteers underwent both fMRI and PET scans. The N-back task was used to assess the neural activities related to working memory. H3 receptor density was measured with the selective PET radioligand [11C] TASP457. The neural activity of the right dorsolateral prefrontal cortex during the performance of the N-back task was negatively correlated with the density of H3 receptors in this region. Conclusions Higher neural activity of working memory was associated with lower H3 receptor density in the right dorsolateral prefrontal cortex. This finding elucidates the role of H3 receptors in working memory and indicates the potential of H3 receptors as a therapeutic target for the cognitive impairments associated with neuropsychiatric disorders. |
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| 書誌情報 |
European Journal of Nuclear Medicine and Molecular Imaging Research (EJNMMI Research) 巻 8, 号 1, p. 48, 発行日 2018-06 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2191-219X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29900481 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s13550-018-0406-4 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1186%2Fs13550-018-0406-4 | |||||
