{"created":"2023-05-15T14:38:02.604671+00:00","id":49078,"links":{},"metadata":{"_buckets":{"deposit":"d6252bf4-b221-4a16-b658-220e5c80b205"},"_deposit":{"created_by":1,"id":"49078","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49078"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049078","sets":["1"]},"author_link":["847412","847401","847408","847409","847403","847422","847411","847402","847405","847404","847419","847417","847420","847421","847416","847406","847410","847413","847415","847414","847407","847418"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"48","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"European Journal of Nuclear Medicine and Molecular Imaging Research (EJNMMI Research)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nThe histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cognitive functions such as working memory. However, the role of prefrontal H3 receptors in working memory has not yet been clarified. Therefore, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) techniques, we aimed to investigate the association between the neural activity of working memory and the density of H3 receptors in the prefrontal cortex.\nFindings\nTen healthy volunteers underwent both fMRI and PET scans. The N-back task was used to assess the neural activities related to working memory. H3 receptor density was measured with the selective PET radioligand [11C] TASP457. The neural activity of the right dorsolateral prefrontal cortex during the performance of the N-back task was negatively correlated with the density of H3 receptors in this region.\nConclusions\nHigher neural activity of working memory was associated with lower H3 receptor density in the right dorsolateral prefrontal cortex. This finding elucidates the role of H3 receptors in working memory and indicates the potential of H3 receptors as a therapeutic target for the cognitive impairments associated with neuropsychiatric disorders.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29900481","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13550-018-0406-4","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://link.springer.com/article/10.1186%2Fs13550-018-0406-4","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2191-219X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Takehito"}],"nameIdentifiers":[{"nameIdentifier":"847401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"847402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"847403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"847404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokokawa, Keita"}],"nameIdentifiers":[{"nameIdentifier":"847405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"847406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"847407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"847408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"847409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"847410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Makiko"}],"nameIdentifiers":[{"nameIdentifier":"847411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Takehito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokokawa, Keita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hidehiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Makiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"847422","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-14"},"publish_date":"2018-06-14","publish_status":"0","recid":"49078","relation_version_is_last":true,"title":["Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:33:36.128936+00:00"}