WEKO3
-
RootNode
アイテム
Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction
https://repo.qst.go.jp/records/49045
https://repo.qst.go.jp/records/49045c355e50d-5bbb-4c65-a017-4e18fe3b4659
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-18 | |||||
| タイトル | ||||||
| タイトル | Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Amino, Mari
× Amino, Mari× Yoshioka, Kouichirou× Furusawa, Yoshiya× Tanaka, Sachie× Kawabe, Noboru× Hashida, Tadashi× Tsukada, Teruyo× Izumi, Masako× Inokuchi, Sadaki× Tanabe, Teruhisa× Ikari, Yuji× 網野 真理× 吉岡 公一郎× 古澤 佳也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Targeted external heavy ion irradiation (THIR) of rabbit hearts 2 weeks after myocardial infarction (MI) reduced the vulnerability of fatal ventricular tachyarrhythmias (VT/VF) in association with the increased connexin43 (Cx43). Increased Cx43 was maintained for at least 1 year in normal rabbits, but the long-term antiarrhythmic effects in the MI model are unknown. We investigated the propensity for late potentials and VT/VF inducibility. Methods: Intracoronary injection of microspheres was performed to induce nontransmural MI in anesthetized eight beagles. Four beagles were treated with THIR (12C6+, 15 Gy) 2 weeks later (MI + THIR group), and four without THIR served as controls (MI group). Signal-averaged electrocardiography, programmed electrical stimulation, immunohistochemical analysis, and echocardiograms were performed at 1 year. Results: Filtered QRS duration was exacerbated after MI and remained unchanged for 1 year in the MI group (118 ± 1.4 ms), but significantly returned toward baseline in the MI + THIR group (109 ± 6.9 ms). Similarly, root mean square voltage of the last 40 ms was exacerbated after MI, but recovered after THIR. VT/VF inducibility decreased to 25% in the MI + THIR group compared with 100% in the MI group. Immunostaining Cx43 expression in cardiac tissues significantly increased by 24–45% in the MI + THIR group. Left ventricular ejection fractions remained within the normal range in both groups. Conclusion: A single exposure of the dog heart to 12C irradiation attenuated vulnerability to ventricular arrhythmia after the induction of MI for at least 1 year through the modulation of Cx43 expression. |
|||||
| 書誌情報 |
Pacing And Clinical Electrophysiology 巻 40, 号 4, p. 379-390, 発行日 2017-04 |
|||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28158934 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/pace.13031 | |||||
Share
Cite as
Amino, Mari, Yoshioka, Kouichirou, Furusawa, Yoshiya, Tanaka, Sachie, Kawabe, Noboru, Hashida, Tadashi, Tsukada, Teruyo, Izumi, Masako, Inokuchi, Sadaki, Tanabe, Teruhisa, Ikari, Yuji, 網野 真理, 吉岡 公一郎, 古澤 佳也, n.d., Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction: Wiley, 379–390 p.
Loading...
