{"created":"2023-05-15T14:38:01.152179+00:00","id":49045,"links":{},"metadata":{"_buckets":{"deposit":"706b83bf-12a0-4f5c-9b81-a1250de3f6cd"},"_deposit":{"created_by":1,"id":"49045","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49045"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049045","sets":["1"]},"author_link":["494655","494653","494650","494658","494652","494649","494659","494651","494654","494657","494661","494656","494662","494660"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"390","bibliographicPageStart":"379","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Pacing And Clinical Electrophysiology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Targeted external heavy ion irradiation (THIR) of rabbit hearts 2 weeks after myocardial infarction (MI) reduced the vulnerability of fatal ventricular tachyarrhythmias (VT/VF) in association with the increased connexin43 (Cx43). Increased Cx43 was maintained for at least 1 year in normal rabbits, but the long-term antiarrhythmic effects in the MI model are unknown. We investigated the propensity for late potentials and VT/VF inducibility.\nMethods: Intracoronary injection of microspheres was performed to induce nontransmural MI in anesthetized eight beagles. Four beagles were treated with THIR (12C6+, 15 Gy) 2 weeks later (MI + THIR group), and four without THIR served as controls (MI group). Signal-averaged electrocardiography, programmed electrical stimulation, immunohistochemical analysis, and echocardiograms were performed at 1 year.\nResults: Filtered QRS duration was exacerbated after MI and remained unchanged for 1 year in the MI group (118 ± 1.4 ms), but significantly returned toward baseline in the MI + THIR group (109 ± 6.9 ms). Similarly, root mean square voltage of the last 40 ms was exacerbated after MI, but recovered after THIR. VT/VF inducibility decreased to 25% in the MI + THIR group compared with 100% in the MI group. Immunostaining Cx43 expression in cardiac tissues significantly increased by 24–45% in the MI + THIR group. Left ventricular ejection fractions remained within the normal range in both groups.\nConclusion: A single exposure of the dog heart to 12C irradiation attenuated vulnerability to ventricular arrhythmia after the induction of MI for at least 1 year through the modulation of Cx43 expression. ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28158934","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/pace.13031","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Amino, Mari"}],"nameIdentifiers":[{"nameIdentifier":"494649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshioka, Kouichirou"}],"nameIdentifiers":[{"nameIdentifier":"494650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"494651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Sachie"}],"nameIdentifiers":[{"nameIdentifier":"494652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawabe, Noboru"}],"nameIdentifiers":[{"nameIdentifier":"494653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashida, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"494654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukada, Teruyo"}],"nameIdentifiers":[{"nameIdentifier":"494655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Izumi, Masako"}],"nameIdentifiers":[{"nameIdentifier":"494656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inokuchi, Sadaki"}],"nameIdentifiers":[{"nameIdentifier":"494657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanabe, Teruhisa"}],"nameIdentifiers":[{"nameIdentifier":"494658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikari, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"494659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"網野 真理","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"494660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉岡 公一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"494661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"494662","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-18"},"publish_date":"2018-05-18","publish_status":"0","recid":"49045","relation_version_is_last":true,"title":["Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:21:34.238262+00:00"}